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Major royal jelly proteins influence the neurobiological regulation of the division of labor among honey bee workers

文献类型： 外文期刊

作者： Fang, Yu 1 ; Feng, Mao 1 ; Ma, Chuan 1 ; Rueppell, Olav 2 ; Li, Jianke 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Apicultural Res, Key Lab Pollinating Insect Biol, Minist Agr, Beijing 100093, Peoples R China

2.Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2L3, Canada

关键词： Task choice; Royal jelly protein; Honeybee; Brain; Neurological regulation

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 225 卷

页码：

收录情况： SCI

摘要： Age-based division of labor among workers is a fundamental life-history trait of many social insects, including the Western honey bee, Apis mellifera L. Extensive studies of the causation of the most pronounced transition from performing tasks in the nest to outside foraging indicate hormonal regulation of complex physiological changes. However, the proximate neurobiological mechanisms that cause the behavioral repertoire to change are still not understood and require novel approaches to be fully characterized. Thus, we established the first comprehensive monoclonal antibody microarray in honey bees with 16,320 antibodies to directly identify proteins in the brain that regulate the transition to foraging. Major royal jelly protein (MRJP) 1 and MRJP3 were identified as po-tential protein effectors and further investigated. A series of experimental manipulations of the workers' behavioral transition led to changes in MRJP1 and MRJP3 quantities in accordance with their presumed func-tional role. Injection of MRJPs into the brain resulted in increased task-reversal from foraging to nursing and decreased task-progression from nursing to foraging, while the latter was increased by injection with MRJP antibodies. Finally, down-regulation of MRJP1 and MRJP3 expression via RNAi injection into the brain increased the transition from in-hive nursing to outside foraging, confirming a causal role of these two proteins in the proximate regulation of behavior and life-history of honey bee workers. Interaction partners of MRJP1 and MRJP3 in the honey bee brain included other regulators of honey bee behavior and life history. Thus, our transformative methodological advancement of proteome analysis in honey bees reveals novel regulators of honey bee behavior, extends our understanding of the functional pleiotropy of MRJPs, and supports a general nutrition-based model of the regulation of the age-based division of labor in honey bees.

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