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Emerging West African Genotype Chikungunya Virus in Mosquito Virome

文献类型： 外文期刊

作者： Xiao, Pengpeng 1 ; Hao, Yujia 1 ; Yuan, Yuge 1 ; Ma, Wenzhou 1 ; Li, Yiquan 2 ; Zhang, He 3 ; Li, Nan 1 ;

作者机构： 1.Wenzhou Univ, Inst Virol, Wenzhou Key Lab Virol & Immunol, Wenzhou, Peoples R China

2.Changchun Univ Chinese Med, Academician Workstn Jilin Prov, Changchun, Peoples R China

3.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China

关键词： Virome; mosquito; Chikungunya virus; phylogenetic analysis; virus variation

期刊名称：VIRULENCE （ 影响因子：5.4； 五年影响因子：5.7 ）

ISSN： 2150-5594

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： We studied the viromes of three dominant mosquito species in Wenzhou, a coastal city in Zhejiang Province, using metavirome sequencing, with 18 viral families identified. Viral sequences were verified by RT-PCR. The JEV E gene was most closely related to the 1988 Korean strain. DENV sequences were most closely related to the 1997 Australian strain. CHIKV-E1-1 was most closely related to the 1983 Senegal strain and belonged to West African genotype CHIKV. Remarkably, this is the first time that a West African genotype of CHIKV has been detected in Zhejiang Province. Mutations in the CHIKV-E1-1 protein A226V may increase infectivity in Ae. albopictus. Three non-conservative mutations of CHIKV-E1-1 (D45H, D70H and V290D) may have an impact on the function. In conclusion, our study reveals the diversity of mosquito-borne viruses and potential emerging outbreaks in the southeast coastal region of China, providing new perspectives for mining the ecological characterization of other important arboviruses.

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