Artemether ameliorates DSS-induced ulcerative colitis by modulating macrophage polarization
文献类型： 外文期刊
作者： Ren, Xinxin 1 ; Li, Yi 1 ; Xu, Jia 5 ; Xu, Ye 6 ; Huang, Kunlun 1 ; Zhai, Baiqiang 4 ; He, Xiaoyun 1 ;
作者机构： 1.China Agr Univ, Minist Educ, Key Lab Funct Dairy, Key Lab Precis Nutr & Food Qual, Beijing 100083, Peoples R China
2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.Minist Agr & Rural Affairs PR China, Key Lab Safety Assessment Genet Modified Organism, Beijing 100083, Peoples R China
4.Zhengzhou Railway Vocat & Tech Colllege, Zhengzhou 451460, Henan, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China
6.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China
关键词： Artemether; Ulcerative colitis; Notch signal pathway; Macrophage; Immunomodulatory
期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.7； 五年影响因子：5.0 ）
ISSN： 1567-5769
年卷期： 2025 年 161 卷
页码：
收录情况： SCI
摘要： Ulcerative colitis (UC) is a type of human intestinal disease with limited therapeutic options and a low cure rate. The difficulty in treating UC is partly attributed to its complex immune regulatory mechanisms. Artemether, a derivatives of artemisinin, has shown significant therapeutic potential in treating immune-related diseases, such as systemic lupus erythematosus and atherosclerosis. This study aimed to explore the potential ameliorative effects and mechanisms of artemether in UC mice. Through in vivo and in vitro experiments, we found that artemether improved colon inflammation and intestinal barrier dysfunction in mice by decreasing the levels of inflammatory factors IL-1 beta and IL-6, promoting the upregulation of tight junction proteins ZO-1 and Occludin, and inhibiting intestinal leakage. These effects may be mediated by regulating Notch signaling activation and suppressing pro-inflammatory M1 macrophages. This discovery provides new potential therapeutic strategies for colitis.
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