文献类型： 外文期刊

作者： Ren, Aiqi ¹ ; Chen, Liying ¹ ; Zhao, Wenjing ¹ ; Shan, Shuhua ² ; Li, Zhuoyu ² ; Tang, Zhaohui ³ ;

作者机构： 1.Taiyuan Normal Univ, Dept Biol, Jinzhong, Peoples R China

2.Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan, Peoples R China

3.Shanxi Acad Agr Sci, Taiyuan, Peoples R China

关键词： Foxtail millet; Soluble dietary fiber; Structural characterization; Colon cancer

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 107 卷

页码：

收录情况： SCI

摘要： Soluble dietary fiber has anti-tumor effect and is closely related to human health. At present the structure of soluble dietary fiber from foxtail millet (FMB-SDF) and its anti-tumor effect remain unclear. In this study, the structure of FMB-SDF was characterized, and its effects on the colon cancer were investigated. The results showed that under optimal extraction conditions the yield of FMB-SDF was 14.25 %. Based on the monosaccharide composition, methylation results and NMR analysis, the preliminary structure of FMB-SDF was inferred to be a glucan. Interestingly, FMB-SDF markedly inhibited the colony formation ability of HCT116 and HT-29 cells and could significantly induce the increase of reactive oxygen species (ROS) and apoptosis of HCT116 and HT-29 cells. The results of animal experiments showed that FMB-SDF could significantly alleviate clinical symptoms of colon cancer in mice. These results provide a theoretical basis for the exploitation and utilization of FMB-SDF against colon cancer.