The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol
文献类型： 外文期刊
作者： Yang, Xizi 1 ; Hu, Ruizhi 1 ; Yao, Liping 1 ; Zhang, Wentao 1 ; Shi, Mingkun 1 ; Gong, Jiatai 1 ; Yuan, Xupeng 2 ; Li, Yanli 1 ; Yan, Jiahao 1 ; Wang, Ying 1 ; Zhang, Qianjin 1 ; He, Ziyu 3 ; Hou, De-Xing 3 ; Fan, Zhiyong 1 ; Zhang, Hongfu 4 ; Chen, Liang 4 ; He, Xi 1 ; He, Jianhua 1 ; Wu, Shusong 1 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha 410128, Peoples R China
2.Coll Anim Sci & Technol, Hunan Biol & Electromech Polytech, Changsha 410127, Peoples R China
3.Kagoshima Univ, Fac Agr, Dept Food Sci & Biotechnol, Kagoshima 8900065, Japan
4.Inst Anim Sci, Chinese Acad Agr Sci, State Key Lab Anim Nutr, Beijing 100081, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2024 年 15 卷 9 期
页码：
收录情况： SCI
摘要： This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model. Results show that maternal weight had a significant positive correlation with litter mortality in mice. A long-term HFD increased body weight and litter mortality with decreased expression of uterine cytochrome oxidase 4 (COX4), which was recovered by resveratrol in mice. Moreover, HFD decreased the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factors-1 (Nrf-1), and phosphorylated adenosine 5 '-monophosphate (AMP)-activated protein kinase (p-AMPK) and increased the expression of phosphorylated extracellular regulated protein kinases (p-ERK) in the uterus. Resveratrol, a polyphenol that can directly bind to the ERK protein, suppressed the phosphorylation of ERK, increased the expression of p-AMPK, PGC-1 alpha and Nrf-1, and decreased litter mortality in mice. This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model.
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