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A porridge-like hydrogel promoted the oral bioavailability of veterinary medicines

文献类型： 外文期刊

作者： Yu, Yinglan 1 ; Liao, Zhiqian 1 ; Luo, Xiaohong 4 ; Zhang, Tengli 1 ; Yu, Zehui 1 ; Liu, Xinrui 1 ; Yao, Hong 5 ; Liu, Xiwang 7 ; Luo, Lei 1 ;

作者机构： 1.Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

2.NMPA Key Lab Res & Evaluat Pharmaceut Preparat & E, Nanjing 210009, Peoples R China

3.Southwest Univ, Yibin Acad, Yibin 644000, Peoples R China

4.Fourth Peoples Hosp Liaocheng City, Dept Clin Lab, Liaocheng 252000, Shandong, Peoples R China

5.Henan Agr Univ, Coll Vet Med, Zhengzhou 450046, Peoples R China

6.Minist Agr & Rural Affairs, Key Lab Qual & Safety Control Poultry Prod, Key Lab Anim Pathogens & Biosafety, Minist Educ, Beijing, Peoples R China

7.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

关键词： Veterinary medicines; Antimicrobials; Porridge-like hydrogel; Oral delivery; Oral absorption

期刊名称：INTERNATIONAL JOURNAL OF PHARMACEUTICS （ 影响因子：5.2； 五年影响因子：5.7 ）

ISSN： 0378-5173

年卷期： 2025 年 677 卷

页码：

收录情况： SCI

摘要： The administration of veterinary medicines via drinking water or feed ingredients is a widely adopted method in intensive livestock and poultry farming due to its convenience and cost-effectiveness. Among these drugs, antimicrobials are extensively used, with over 70% of global antimicrobial consumption attributed to veterinary applications. However, the misuse of antimicrobials in livestock has been identified as a significant driver of drug resistance, as well as contributing to other adverse health and environmental impacts. Moreover, certain antimicrobials, such as florfenicol, exhibit limited oral bioavailability due to their low water solubility and permeability, which can compromise their therapeutic efficacy. To address these challenges, this study introduces a novel porridge-like hydrogel designed to enhance the oral absorption of antimicrobials, thereby improving their therapeutic effectiveness. Sodium alginate (SA), a natural polysaccharide polymer, was employed as a protective barrier to shield the antimicrobials from degradation by gastric juices, ensuring drug integrity until release in the intestine. This formulation facilitates excellent mixing with feed, resulting in significantly increased oral bioavailability of the antimicrobials. In a Salmonella-infected chicken model, the orally administered florfenicol-loaded SA hydrogel significantly reduced mortality rates compared to conventional delivery methods. Furthermore, this SA hydrogel can enhance the oral bioavailability of a range of poorly absorbed medications, demonstrating its potential as a versatile oral delivery system. These findings suggest that the porridge-like hydrogel represents a novel promising approach for the oral delivery of veterinary medicines, offering a more effective alternative to traditional formulations.

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