The VP1 Protein of Porcine Teschovirus Inhibits the Innate Immune Response to Viral Infection by Blocking MDA5 Activation
文献类型： 外文期刊
作者： Li, Yuying 1 ; Zhang, Xinyu 2 ; Zhao, Baopeng 2 ; Zhao, Chenchen 2 ; Lei, Xiaoxiao 2 ; Huang, Haixin 2 ; Li, Chengkai 2 ; Zheng, Min 3 ; Lan, Tian 2 ; Sun, Wenchao 2 ; Lu, Huijun 4 ;
作者机构： 1.Zhejiang Univ, Inst Prevent Vet Med, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
2.Wenzhou Univ, Wenzhou 325035, Zhejiang, Peoples R China
3.Guangxi Ctr Anim Dis Control & Prevent, Nanning 530001, Guangxi, Peoples R China
4.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130000, Jilin, Peoples R China
期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）
ISSN： 1865-1674
年卷期： 2024 年 2024 卷
页码：
收录情况： SCI
摘要： Porcine teschovirus (PTV) can cause reproductive dysfunction and respiratory diseases, with high mortality rates for sick pigs. Among Picornaviridae family virus-encoded proteins, the VP1 structural protein is critical for viral immune evasion. However, whether PTV VP1 inhibits the type I interferon (IFN) response remains unknown. Here, it shows that the PTV VP1 protein significantly hinders the activation of NF-kappa B, impairing Sendai virus-induced expression of beta IFN (IFN-beta). Further studies revealed that VP1 targets and interacts with the MDA5 factor in the RIG-I like receptors pathway. More importantly, the VP1 protein interacts with the caspase activation and recruitment domain and Hel domains of MDA5, blocking IFN-beta expression. Our findings provide evidence about the VP1 protein of PTV hinders MDA5 activation and may represent a viral mechanism to escape the innate immune response.
- 相关文献
作者其他论文 更多>>
-
Insights into mechanism of 1-hydroxy-2-naphthoic acid accumulation during phenanthrene degradation by Stutzerimonas frequens SL-6
作者：Guo, Liwei;Zhang, Xinyu;Hou, Qiang;Zhao, Baisuo;Wang, Haisheng;Wei, Hailei;Gu, Yilin;Zhang, Xinyu
关键词：Stutzerimonas frequens; Phenanthrene; Oxygenated PAHs; 1-Hydroxy-2-naphthoic acid
-
Interfacial and foaming properties of plant and microbial proteins: Comparison of structure-function behavior of different proteins
作者：Zhang, Xinyu;Liu, Zhe;Ma, Xiaojie;Zheng, Yicheng;Hu, Hui;Jiao, Bo;Wang, Qiang;Shi, Aimin;McClements, David Julian;Wang, Qiang;Wang, Qiang;Shi, Aimin
关键词：Plant and microbial proteins; Structural composition; Physicochemical properties; Foaming properties; Correlation analysis
-
Genetic, metabolomic and transcriptomic analyses of the cotton yellow anther trait
作者：Liang, Qian;Feng, Xiaokang;Wang, Xuefeng;Ma, Xiaohu;Liang, Rui;Liu, Feng;Zhang, Xinyu;Sun, Jie;Xue, Fei;Hu, Daowu;He, Shoupu;Jin, Yanlong;Zhu, Qian-Hao;Zhu, Huaguo
关键词：Carotenoid biosynthesis; Flavonoid biosynthesis; PSY; Wild cotton; Yellow anther
-
CardiOT: Towards Interpretable Drug Cardiotoxicity Prediction Using Optimal Transport and Kolmogorov--Arnold Networks
作者：Zhang, Xinyu;Zhuo, Linlin;Wang, Hao;Du, Zhenya;Fu, Xiangzheng;Cao, Dongsheng;Xie, Boqia;Li, Keqin
关键词：Drugs; Compounds; Predictive models; Ions; Chemicals; Safety; Data models; Accuracy; Toxicology; Prediction algorithms; Cardiac drug safety; compound cardiotoxicity (CCT); inhibitory effects of drugs; Kolmogorov--Arnold networks (KANs); optimal transport (OT); uneven distribution and data scarcity
-
Overexpression of TaSnRK2.9s Improves Plant Growth and Development in Rice (Oryza sativa L.)
作者：Rehman, Shoaib Ur;Zhang, Zijin;Chen, Jing;Rehman, Shoaib Ur;Khan, Zulqurnain;Waheed, Ummara;Hasnain, Muhammad Usama;Rehman, Shoaib Ur;Mao, Xinguo;Li, Yuying;Wang, Jingyi;Jing, Ruilian;Sajjad, Muhammad
关键词：cell membrane stability; common wheat; drought; gene expression; root development; transgenic rice
-
Extreme Wetness Reduces Soil Microbial Residue Carbon More Substantially Than Extreme Drought Across Grassland Ecosystems
作者：Yu, Yingchao;Liu, Shuang;Pan, Junxiao;Zhu, Juntao;Zong, Ning;Zhang, Xinyuan;Zhang, Xinyu;Yu, Yingchao;Zhu, Juntao;Zhang, Xinyuan;Zhang, Xinyu;Liu, Shuang;Wu, Honghui;Wu, Honghui;An, Hui;Diao, Huajie;Zuo, Xiaoan;Wei, Cunzheng;Zhang, Fawei;Yu, Qiang
关键词：amino sugar; aridity index; China global change network; enzyme activity; increased precipitation; nitrogen; reduced precipitation
-
A Raf-Like MAPKKK Gene TaHT1 Controls Drought Tolerance and Primary Root Length in Wheat
作者：Wang, Min;Li, Chaonan;Wang, Jingyi;Li, Yuying;Zhang, Yanfei;Yang, Lili;Zhang, Yining;Zhang, Jie;Zhang, Zihui;Yan, Wen;Zuo, Yuang;Zhao, Qiancheng;Li, Long;Mao, Xinguo;Jing, Ruilian
关键词：drought tolerance; functional marker; primary root length;
TaHT1 ;TaSnRK2.10
