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Di-p-Coumaroyl Spermidine From Bee Pollen Alleviates Chronic Nonbacterial Prostatitis

文献类型： 外文期刊

作者： Zhang, Jiawen 1 ; Qiao, Jiangtao 2 ; Zhang, Yu 4 ; Zhu, Hequan 4 ; Haubruge, Eric 3 ; Liu, Liqiang 2 ; Dong, Jie 4 ;

作者机构： 1.Capital Med Univ, Sch Basic Med Sci, Beijing, Peoples R China

2.Hebei Univ Engn, Sch Life Sci & Food Engn, Handan, Peoples R China

3.Univ Liege, Gembloux Agrobio Tech, Terra Res Ctr, Gembloux, Belgium

4.Chinese Acad Agr Sci, Inst Apicultural Res, State Key Lab Resource Insects, Beijing, Peoples R China

5.Jiangsu Beevip Biotechnol Co Ltd, Taizhou, Peoples R China

关键词： AMPK/mTOR; anti-inflammation; di-p-coumaroyl spermidine; phenolamides; rapeseed bee pollen

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.8； 五年影响因子：4.5 ）

ISSN： 2048-7177

年卷期： 2025 年 13 卷 6 期

页码：

收录情况： SCI

摘要： Bee pollen and its extracts have been used for decades as therapeutic agents or health food supplements to alleviate chronic nonbacterial prostatitis (CNP). However, the functional compounds in bee pollen that are anti-CNP remain still unclear. In this study, we evaluated the anti-CNP properties of six principal phenolamides in bee pollen. Our results provide compelling evidence that the anti-CNP property of bee pollen may be ascribed to its abundance of phenolamides. Particularly, di-p-Coumaroyl spermidine can alleviate CNP by upregulating autophagy via the AMPK/mTOR signaling pathway and regulating gut microbiota, based on the cellular and rat models. Additionally, our finding may provide a novel insight into the gut-prostate axis by regulating di-p-Coumaroyl spermidine. This is the first report that di-p-Coumaroyl spermidine in bee pollen possesses the anti-prostatitis function. This paper will likely be helpful further to develop functional foods, personalized nutraceuticals, and medicine from bee pollen.

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