Phylogenetic and pathogenic characterization of lumpy skin disease virus circulating in China
文献类型： 外文期刊
作者： Ren, Shanhui 1 ; Chen, Haotai 1 ; Yuan, Lvfeng 1 ; Yang, Xue 2 ; Afera, Tadele Berihun 1 ; Rehman, Zaib Ur 3 ; Wang, Huibao 1 ; Wang, Xiangwei 1 ; Ma, Chunling 2 ; Lin, Yuguang 1 ; Qiu, Xusheng 5 ; Yin, Xiangping 1 ; Sun, Yuefeng 1 ;
作者机构： 1.Lanzhou Univ, Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent,Coll Vet, Lanzhou 730030, Peoples R China
2.Gansu Agr Univ, Coll Vet Med, Lab Vet Microbiol, Lanzhou 730070, Peoples R China
3.PMAS Arid Agr Univ, Fac Vet & Anim Sci, Dept Poultry Sci, Rawalpindi 46300, Pakistan
4.Tarim Univ, Coll Anim Sci & Technol, Lab Vet Microbiol, Alar 843300, Peoples R China
5.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Dept Avian Infect Dis, Shanghai 200241, Peoples R China
关键词： Dissemination; Lumpy skin disease virus; Phylogenetic; Pathogenicity; Surveillance
期刊名称：VIROLOGY （ 影响因子：3.7； 五年影响因子：3.2 ）
ISSN： 0042-6822
年卷期： 2023 年 585 卷
页码：
收录情况： SCI
摘要： The genomic characterization of emerging pathogens is critical for unraveling their origin and tracking their dissemination. Lumpy skin disease virus (LSDV) is a rapidly emerging pathogen in Asia including China. Although the first Lumpy skin disease (LSD) outbreak was reported in 2019, the origin, transmission, and evolutionary trajectory of LSDV in China have remained obscure. The viral genome of a circulating LSDV strain in China, abbreviated LSDV/FJ/CHA/2021, was sequenced using the next-generation sequencing technique. The morphology and cytoplasmic viral factory of these LSDV isolates were observed using transmission electron microscopy. Subsequently, the genomic characterization of this LSDV isolate was systematically analyzed for the first time using the bioinformatics software. The current study revealed that several mutations in the genome of LSDV isolates circulating in China were identified using single nucleotide polymorphisms (SNPs) analysis, an instrument to evaluate for continuous adaptive evaluation of a virus. Furthermore, phylogenomic analysis was used to identify the lineage using the whole genome sequences of 44 LSDV isolates. The result revealed that the isolates from China were closely similar to that of the LSDV isolates from Vietnam, which are divided into a monophyletic lineage sub-group I. The SNPs and Simplot analysis indicate no significant occurrence of the recombinant event on the genome of LSDV isolates in China. Notably, the live virus challenge experiment demonstrated that the pathogenic characterization of this LSDV isolate belongs to a virulent strain. Collectively, we gain the first insight into the evolutionary trajectory, spatiotemporal transmission, and pathogenic characterization of circulating LSDV in China. This study provides a unique reference for risk assessment, guiding diagnostics, and prevention in epizootic and non-epizootic areas.
- 相关文献
作者其他论文 更多>>
-
Comparison of fatty acid characteristics in human milk, bovine milk, and infant formula for better emulation
作者：Yang, Xue;Meng, Lu;Rahman, Ashikur;Wang, Jiaqi;Zheng, Nan;Yang, Xue;Meng, Lu;Rahman, Ashikur;Wang, Jiaqi;Zheng, Nan;Yang, Xue;Meng, Lu;Rahman, Ashikur;Wang, Jiaqi;Zheng, Nan;Yang, Xue;Meng, Lu;Rahman, Ashikur;Wang, Jiaqi;Zheng, Nan
关键词：
-
Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation
作者：Dai, Jun;Feng, Yiyi;Liao, Ying;Tan, Lei;Sun, Yingjie;Song, Cuiping;Qiu, Xusheng;Ding, Chan;Dai, Jun;Long, Hong;Ding, Chan
关键词：dexamethasone; coronavirus; infectious bronchitis virus; Na+/H(+)exchanger 3; pH
-
Development of a blocking ELISA employing a VP1-specific monoclonal antibody for the detection of DHAV3 antibodies
作者：Song, Cuiping;Li, Tianyuan;Wang, Jing;Yang, Wenjing;Tang, Ning;Qu, Yang;Li, Siyu;Qiu, Xusheng;Tan, Lei;Sun, Yingjie;Liao, Ying;Ding, Chan;Wang, Jing;Li, Siyu;Guo, Peidong;Ding, Chan
关键词：Antibody detection; Blocking ELISA;Duck hepatitis A virus type 3
-
SHORT INTERNODE1 regulates the activity of MADS transcription factors during rice floral organ development
作者：Duan, Erchao;Teng, Xuan;Xu, Huan;Ma, Wenyu;Zhang, Desheng;Zhang, Rushuang;Gu, Chuanwei;Zhang, Yipeng;Chen, Rongbo;Chen, Xiaoli;Dong, Hui;Zhang, Yuanyan;Yang, Xue;Zhou, Lei;Liu, Shijia;Liu, Xi;Tian, Yunlu;Jiang, Ling;Wang, Yihua;Wan, Jianmin;Feng, Miao;Lin, Qibing;Wang, Haiyang
关键词：
-
La Sota-vectored recombinant vaccine with chimeric hemagglutinin-neuraminidase for enhanced protection against highly pathogenic pigeon paramyxovirus type 1
作者：Zhang, Shan;Liu, Dahu;Zhang, Guangzhi;Liang, Ruiying;Liang, Lin;Tang, Xinming;Hou, Shaohua;Ding, Jiabo;Zhang, Shan;Liu, Dahu;Zhang, Guangzhi;Liang, Ruiying;Liang, Lin;Tang, Xinming;Hou, Shaohua;Ding, Jiabo;Qiu, Xusheng;Zhang, Ziyan;Ding, Chan;Liu, Baojing
关键词：Pigeon Paramyxovirus Type 1; antigenic difference; biological characteristic; immune efficacy
-
Application of multi-omics technology in pathogen identification and resistance gene screening of sheep pneumonia
作者：Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Yuan, Lvfeng;Liu, Jia;Zhang, Xiaoxue;Peng, Jie
关键词：Sheep; Multi-omics; Pathogen identification;
Mycoplasma ovipneumoniae ; Genome-wide association study; Disease-resistant breeding -
The CRM1-dependent NES257-266 motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence
作者：Zhang, Yaodong;Tan, Lei;Mu, Daoe;Zhang, Ziyan;Song, Cuiping;Qu, Yang;Tang, Ning;Liao, Ying;Ding, Chan;Sun, Yingjie;Qiu, Xusheng;Dai, Jun;Ding, Chan
关键词：Newcastle disease virus; M protein; NES; CRM1; replication; virulence
