N6-Methyladenosine Modification Regulates Prunus Necrotic Ringspot Virus Infection in Cucumis sativus
文献类型： 外文期刊
作者： Dong, Zhenfei 1 ; Liu, Na 2 ; Zhang, Zhixiang 2 ; Wang, Hongqing 1 ; Li, Shifang 2 ; Zhan, Binhui 2 ;
作者机构： 1.China Agr Univ, Coll Hort, Dept Fruit Sci, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing 100193, Peoples R China
3.Chinese Acad Inspect & Quarantine, Ctr Biosafety, Sanya 572024, Hainan, Peoples R China
关键词： epitranscriptomes; N6-methyladenosine; PNRSV; m(6)A readers; phenylalanine ammonia-lyase
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 19 期
页码：
收录情况： SCI
摘要： N6-methyladenosine (m(6)A) is a common epigenetic modification found in eukaryotic RNA. Recent studies have increasingly highlighted the importance of m(6)A modification in plant defense against viruses. In this investigation, we found that prunus necrotic ringspot virus (PNRSV) infection affected the m(6)A modification process. Plant transcriptomes and epitranscriptomes were sequenced to coanalyze the dynamic changes of m(6)A modifications after PNRSV infection. Further studies revealed that the silencing of evolutionarily conserved C-terminal region (ECTs), encoding m(6)A readers, led to increased PNRSV accumulation, indicating that ECTs confer resistance to PNRSV. Additionally, we demonstrated that UPF3 and SMG7, which are involved in non-sense-mediated mRNA decay pathways, as well as phenylalanine ammonia-lyase (PAL), a well-known key enzyme in plant defense and an identified m(6)A-modified gene following PNRSV infection, play crucial roles in regulating PNRSV infection. These findings provide new insights into understanding PNRSV infection and further elucidate the role of m(6)A in modulating viral infection in plants.
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