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Simultaneous Detection of 21 Kinds of Mycotoxins and Their Metabolites in Animal Plasma with Impurity Adsorption Purification Followed by Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

作者： Wang Rui-Guo 1 ; Su Xiao-Ou 1 ; Wang Pei-Long 1 ; Zhang Wei 1 ; Xue Yan 2 ; Li Yu 2 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agr Prod, Key Lab Agrifood Safety & Qual, Minist Agr, Beijing 10081, Peoples R China

2.Alltech Biol Prod China Co LTD, Beijing 100600, Peoples R China

关键词： Liquid chromatography-tandem mass spectrometry;Plasma;Mycotoxins;Residue

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）

ISSN： 0253-3820

年卷期： 2017 年 45 卷 2 期

页码：

收录情况： SCI

摘要： A novel method for simultaneous detection of mycotoxins (e.g., aflatoxin B-1) or their metabolic residues in animal plasma with impurity adsorption purification followed ultra performance liquid chromatography. tandem mass spectrometry (UPLC-MS/MS) was developed. Extraction of mycotoxins and their metabolites from animal plasma sample was performed with 0.1% formic acid. acetonitrile solution after addition of sodium chloride and hydrous magnesium sulfate. The extract was then dehydrated and purified with hydrous magnesium sulfate, C-18, primary secondary amine, and alumina-A 3 mL of the supernatant was evaporated and re. dissolved with 0.5 mL of 0.1% formic acid aqueous solution/acetonitrile (70.30, V/V) for UPLC-MS/MS detection. The analytes were separated by a C-18 column utilizing gradient elution with 0. 1% formic acid aqueous solution containing 0.5 mmol of ammonium acetate and 0. 1% formic acid. methanol solution, and finally detected by tandem mass spectrometry in positive/negative ESI mode. Identification and quantification were achieved by LC-MS/MS with multi. reaction monitoring (MRM). Good linearity in response was obtained in the analytes concentration range of 0.05-100 ng/mL with correlation coefficients larger than 0.99. The limits of quantification (S/N = 10) were around 0.05-0.5 ng/mL. The recoveries of mycotoxins and their metabolites spiked in blank plasma samples were in the range of 62.0% - 116.4%, with relative standard deviations (RSDs) less than 19. 0%.

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