您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Gene expression analysis of host spleen responses to Marek's disease virus infection at late tumor transformation phase

文献类型： 外文期刊

作者： Lian, L. 1 ; Qu, L. J. 1 ; Sun, H. Y. 1 ; Chen, Y. M. 1 ; Lamont, S. J. 2 ; Liu, C. J. 3 ; Yang, N. 1 ;

作者机构： 1.China Agr Univ, Dept Anim Genet & Breeding, Natl Engn Lab Anim Breeding, MOA Lab Anim Genet & Breeding,Coll Anim Sci & Tec, Beijing 100193, Peoples R China

2.Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA

3.Chinese Acad Agr Sci, Div Avian Infect Dis, Harbin Vet Res Inst, Harbin 150001, Peoples R China

关键词： Marek's disease;host response;gene expression;tumor transformation

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN： 0032-5791

年卷期： 2012 年 91 卷 9 期

页码：

收录情况： SCI

摘要： Marek's disease is a viral neoplastic disease of chickens caused by Marek's disease virus (MDV). Gene expression patterns have been investigated at different MDV infection stages, but there is limited research about the late tumor transformation phase. In this experiment, 44K Agilent chicken genomewide expression micromays were used to profile differential expression in tumorous spleens (TS) from severely morbid chickens and apparently normal spleens from survivors (SS) after MDV infection and expression in noninfected spleens (NS) from controls. There were 4,317 differentially expressed (DE) genes in TS versus NS. However, no DE genes were detected in SS versus NS, suggesting that maintenance of, or return to, homeostasis of gene activity in survivor spleens. Down-regulated genes in tumorous spleens mainly enriched in the cytokine-cytokine receptor interaction pathway, and commonly investigated genes in Marek's disease study, IL6, IL18, IFNA, and IFNG were nondifferentially expressed, which indicates host inflammatory response was impaired. The IL10 and TNFRSF8 genes were upregulated in tumorous spleens. We speculated that 1110 might be exploited by MDV to escape from host immune surveillance, as reported for Epstein-Barr virus, which stimulated T cells secreting IL10 to subvert immune response. Previous study reported that transcription from TNFRSF8 promoter could be enhanced by MDV oncogene Meq. In this study, the increased expression of TNFRSF8 indicated interaction between MDV and TNFRSF8, which might facilitate pathogenesis and tumor transformation. The expression of many members in IGF system was changed in tumorous compared with noninfected spleens. The downregulation of IGFBP7 was considered to be associated with MD lymphoma transformation. Gene expression change of multiple regulatory pathways indicated their involvements in facilitating tumor transformation.

  • 相关文献

[1]Expression profiles of genes within a subregion of chicken major histocompatibility complex B in spleen after Marek's disease virus infection. Lian, L.,Qu, L. J.,Zheng, J. X.,Chen, Y. M.,Xu, G. Y.,Yang, N.,Liu, C. J.,Zhang, Y. P.. 2010

[2]Cloning and Expression of the Chloroplast Copper/Zinc-Superoxide Dismutase Gene in Upland Cotton （Gossypium hirsutum L.）. Hu Genhai,Yu Shuxun,Fan Shuli,Song Meizhen. 2007

[3]Host Differences Affecting Resistance and Susceptibility of the Second Generation of a Pekin Duck Flock to Duck Hepatitis A Virus Genotype 3. Wang, Xiaoyan,Zhang, Jiaojiao,Meng, Runze,Jiang, Yong,Liang, Suyun,Zhang, Yunsheng,Xie, Ming,Zhou, Zhengkui,Hou, Shuisheng. 2017

[4]Plasma proteomic profiles of healthy and mastitic cows - host responses to bovine mastitis. Niu, LiLi,Niu, LiLi,Wei, CaiHong,Du, LiXin. 2013

[5]Protective efficacy of a novel recombinant Marek's disease virus vector vaccine against infectious bursal disease in chickens with or without maternal antibodies. Li, Kai,Liu, Yongzhen,Zhang, Yanping,Gao, Li,Liu, Changjun,Cui, Hongyu,Qi, Xiaole,Gao, Yulong,Zhong, Li,Wang, Xiaomei.

[6]Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration. Han, Bo,Lian, Ling,Li, Xin,Zhao, Chunfang,Qu, Lujiang,Yang, Ning,Liu, Changjun,Liu, Changjun. 2016

[7]Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek's disease in Chinese specific pathogen-free BWEL chickens. Gao, Caixia,Han, Lingxia,Liu, Jiasen,Jiang, Qian,Guo, Dongchun,Qu, Liandong,Han, Jianlin.

[8]Chicken gga-miR-130a targets HOXA3 and MDFIC and inhibits Marek's disease lymphoma cell proliferation and migration. Han, Bo,Lian, Ling,Li, Xin,Zhao, Chunfang,Qu, Lujiang,Yang, Ning,Liu, Changjun,Song, Jiuzhou.

[9]Chicken gga-miR-181a targets MYBL1 and shows an inhibitory effect on proliferation of Marek's disease virus-transformed lymphoid cell line. Lian, Ling,Li, Xin,Zhao, Chunfang,Han, Bo,Qu, Lujiang,Yang, Ning,Song, Jiuzhou,Liu, Changjun.

[10]Characterization of Copy Number Variation's Potential Role in Marek's Disease. Xu, Lingyang,He, Yanghua,Ding, Yi,Sun, Guirong,Carrillo, Jose Adrian,Li, Yaokun,Ghaly, Mona M.,Ma, Li,Song, Jiuzhou,Xu, Lingyang,Liu, George E.,Xu, Lingyang,Sun, Guirong,Li, Yaokun,Ghaly, Mona M.,Zhang, Huanmin. 2017

[11]Protein restriction followed by tea li men tat ion influenced immune system and transcriptome of lamb. K. Cm,B. Wang,N.F. Zhang. 2019

[12]Gene Expression Profile of Osteoblast-Like Cells on Calcium Phosphate Biomaterials. Taro Takemura,Hongsong Fan,Toshiyuki lkoma,Junzo Tanaka,Nobutaka Hanagata. 2007

[13]Effect of Acid Treated Hydroxyapatite on Osteoblast Maturation. Taro Takemura,Toshiyuki Ikoma,Nobutaka Hanagata. 2008

[14]Chondrocyte gene expression under applied surface motion. Sibylle Grad,Cynthia R. Lee,Markus A. Wimmer,Mauro Alin. 2006

[15]Analysis of Differentially Expressed Genes in Genic Male Sterility Cotton (Gossypium hirsutum L.) Using cDNA-AFLP. Xiaoding Ma,Chaozhu Xing,Liping Guo,Yangcang Gong,Hailin Wang,Yunlei Zhao,Jianyong Wu. 2007

[16]Differential Gene Expression Between Hybrids and Their Parents During the Four Crucial Stages of Cotton Growth and Development. Zhao Yun-lei,Yu Shu-xun,Xing Chao-zhu,Fan Shu-li,Song Mei-zhen,Ye Wu-wei. 2009

[17]Isolation and expression profiling of GhNAC transcription factor genes in cotton (Gossypium hirsutum L.) during leaf senescence and in response to stresses. Syed Tariq Shah,Chaoyou Pang,Shuli Fan,Meizhen Song,Saima Arain,Shuxun Yu.

[18]Isolation and Characterization of an ERF Transcription Factor Gene from Cotton (Gossypium barbadense L.). Xianpeng Meng,Fuguang Li,Chuanliang Liu,Chaojun Zhang,Zhixia Wu,Yajuan Chen.

[19]RNA-Seq-based analysis of changes in Borrelia burgdorferi gene expression linked to pathogenicity. Wu, Qiong,Guan, Guiquan,Liu, Zhijie,Li, Youquan,Luo, Jianxun,Yin, Hong. 2015

[20]Comparative Proteomic Analysis Reveals Differential Root Proteins in Medicago sativa and Medicago truncatula in Response to Salt Stress. Long, Ruicai,Zhang, Tiejun,Kang, Junmei,Cong, Lili,Gao, Yanli,Yang, Qingchuan,Li, Mingna,Sun, Yan,Liu, Fengqi. 2016

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台