您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Suppressing IGF2R mitigates hypoxia-induced apoptosis by reducing the expression of pro-apoptotic factor BAX

文献类型： 外文期刊

作者： Guo, Xiaorong 1 ; Fan, Xinhao 3 ; Xie, Chundi 1 ; Afe, Ayoola Ebenezer 1 ; Yang, Yalan 3 ; Zhou, Rong 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China

2.Liaocheng Univ, Liaocheng 252059, Peoples R China

3.Chinese Acad Agr Sci, Kunpeng Inst Modern Agr Foshan, Inst Agr Genom Inst Shenzhen, Foshan 528226, Peoples R China

关键词： Hypoxia; IGF2R; Apoptosis

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 284 卷

页码：

收录情况： SCI

摘要： Oxidative stress caused by hypoxia can lead to serious bodily damage and functional degradation. Our previous study in pigs showed that the insulin-like growth factor II receptor (IGF2R) gene might participate in the process of hypoxia adaptability. To investigate the function and mechanism of IGF2R in cellular hypoxia tolerance, we analyze the effect of IGF2R on cell survival capacity under hypoxia conditions in intestinal porcine enterocyte cell line (IPEC-J2) cells. The results show that under hypoxia condition (3% O2), cell viability is significantly reduced, the expression of IGF2R and cell apoptosis are significantly increased. Functional analysis suggests that suppressing IGF2R expression under hypoxia does not affect cell cycle and cell proliferation but increases cellular viability. Meanwhile, the expression of the pro-apoptotic gene BAX is reduced, the hypoxia-induced apoptosis is rescued, and cell survival is significantly improved. Transcriptome analysis suggests that global gene expression changes in knockdown IGF2R under hypoxia, IGF2R may regulate apoptosis through oxidative phosphorylation. Our findings demonstrate that suppressing IGF2R expression under hypoxia can rescue hypoxia-induced cell injury by reducing the expression of BAX, highlighting the potential ability of IGF2R regulation for the treatment of hypoxia stress.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台