Bioactive nanocomposite hydrogel with synergistic antibacterial and cytoprotective functions: Multi-target keratinocyte modulation for infected wound regeneration
文献类型： 外文期刊
作者： Zhou, Enning 1 ; Zhu, Yuying 1 ; Chen, Gang 2 ; Liu, Dongyuan 3 ; Zhao, Liuwei 1 ; Wang, Miao 1 ; Wu, Liming 1 ; Li, Qiangqiang 1 ;
作者机构： 1.Chinese Acad Agr Sci, State Key Lab Resource Insects, Inst Apicultural Res, Beijing 100093, Peoples R China
2.Beijing Technol & Business Univ, Sch Food & Hlth, Beijing 100048, Peoples R China
3.Capital Med Univ, Beijing Luhe Hosp, Dept Neurosurg, Beijing 101149, Peoples R China
关键词： Bacterial infected wound healing; Carbon dots; Multifunctional hydrogels; Royal jelly and honey; Bioactive nanomaterials
期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）
ISSN： 1385-8947
年卷期： 2025 年 520 卷
页码：
收录情况： SCI
摘要： Pathogenic bacterial infections are responsible for one-eighth of global mortality, with Staphylococcus aureusinduced wound infections serving as a critical example that presents significant challenges due to antibiotic resistance and impaired tissue regeneration. To address this issue, we innovatively synthesized 10-hydroxy-2decenoic acid-functionalized carbon dots (10-HDA@CDs) using bioactive royal jelly derivatives and further incorporated them into a honey-reinforced alginate-dopamine hydrogel (10-HDA@CDs@HON/SA-DA). The resultant composite hydrogel demonstrated synergistic antibacterial efficacy, achieving over 99.9 % clearance of S. aureus. In vivo studies revealed accelerated healing of infected wounds through mechanisms including inflammation inhibition, promotion of myofibroblasts proliferation, and enhanced angiogenesis. Single-cell transcriptomics unveiled the multi-cytoprotective mechanism of 10-HDA@CDs@HON/SA-DA hydrogel against S. aureus pathogenesis by suppressing chronic inflammation, oxidative stress, and DNA damage, while enhancing keratinocyte functions to expedite infected wound healing. This work pioneers a "nano-bio" therapeutic strategy with three key innovations: integrating natural bioactive molecules with nanomaterials; modulating the multitarget crosstalk between infection and microenvironment; and accelerating antibiotic-free healing via keratinocyte phenotypic restoration. Our findings validate natural food-derived nanomaterials as high-safety and sustainable alternatives for integrated wound management, paving the way for multifunctional nanotherapeutics in precision dermatology.
- 相关文献
作者其他论文 更多>>
-
Trace phospholipid and fatty acid differences between dairy and plant-based milk products by 1 H and 31 P NMR spectroscopy combined with multivariate statistical analysis
作者：Wang, Tongtong;Tan, Sijia;Li, Liang;Jiang, Bin;Wang, Dan;Liu, Qingyi;Chen, Gang
关键词：Dairy cream; Butter; Plant-based cream; Margarine; Multivariate statistical analysis
-
Polysaccharides from Astragalus membranaceus Bunge alleviate LPS-induced neuroinflammation in mice by modulating microbe-metabolite-brain axis and MAPK/NF-κB signaling pathway
作者：Liu, Dongyuan;Hou, Ziming;Wang, Hao;Zhu, Yuying;Li, Qiangqiang
关键词：Astragalus membranaceus Bunge; polysaccharides; Anti-neuroinflammation; Microbe-metabolite-brain axis
-
Evaluation and Validation of Colloidal Gold Immunochromatographic Qualitative Testing Products for the Detection of Emamectin Benzoate, Isocarbophos, and Fipronil in Cowpea Samples
作者：Song, Anning;Wang, Miao;She, Yongxin;Jin, Maojun;Cao, Zhen;Wang, Jing;Wang, Miao;She, Yongxin;Jin, Maojun;Cao, Zhen;Wang, Jing;Abd El-Aty, A. M.;Abd El-Aty, A. M.
关键词：food safety; colloidal gold immunochromatographic qualitative testing; cowpea; pesticide residue; emamectin benzoate; isocarbophos; fipronil
-
Molecularly imprinted SERS sensor on paper for benzoic acid detection in rice vinegar
作者：Zhang, Jianpeng;Zhang, Guohua;Zhang, Jianpeng;Wang, Miao;She, Yongxin;Jin, Fen;Jin, Maojun;Wang, Jing;Zhang, Jianpeng;Wang, Miao;She, Yongxin;Jin, Fen;Jin, Maojun;Wang, Jing;Abd El-Aty, A. M.;Abd El-Aty, A. M.
关键词：Benzoic acid; Surface-enhanced Raman scattering; Vinegar; Molecularly imprinted polymer
-
Advances in conventional and innovative anti-allergic agents for managing food allergies: from mechanisms to challenges
作者：Zhu, Yuying;Zhou, Enning;Wu, Liming;Li, Qiangqiang;Chen, Gang;Kamal-Eldin, Afaf
关键词：food allergy; anti-allergic agents; natural bioactive ingredients; nano/micro-carriers; nanoparticles
-
Facile synthesis of flower-cluster ZIF nanocarriers: Performance in controlled release of thiamethoxam and insecticidal activity
作者：Ding, Xin;Yang, Kexin;Yang, Xin;Zhou, Jie;Wang, Miao;Lin, Zhihao;Xu, Donghui;Chen, Ge;Xu, Xiaomin;Qin, Lin;Liu, Guangyang;Yang, Kexin;Zhang, Yaowei;Jiao, Bining
关键词：ZnCo-ZIF; Nanocarriers; Thiamethoxam; Insecticidal activity; Metal-phenolic network
-
Assessing the distribution and human health risks of cationic surface-active agents in honey from China
作者：Ren, Caijun;Qi, Suzhen;Li, Qiangqiang;Wang, Miao;Wu, Liming;Zhao, Liuwei;Luo, Teng;Shen, Haona
关键词：Benzalkonium chloride; Cationic surface-active agents; Chlorhexidine; Honey; Risk assessment
