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Associations between polymorphisms of the STAT1 gene and milk production traits in water buffaloes

文献类型： 外文期刊

作者： Deng, T. X. 1 ; Pang, C. Y. 1 ; Lu, X. R. 1 ; Zhu, P. 1 ; Duan, A. Q. 1 ; Liang, X. W. 1 ;

作者机构： 1.Chinese Acad Agr Sci, Buffalo Res Inst, Minist Agr, Key Lab Buffalo Genet Breeding & Reprod Technol, Nanning, Peoples R China

关键词： association analysis;buffalo;single nucleotide polymorphisms;STAT1

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：3.159； 五年影响因子：2.912 ）

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收录情况： SCI

摘要： Signal transducer and activator of transcription 1 (STAT1) is an important regulator of mammary gland differentiation and cell survival that has been regarded as a candidate gene affecting milk production traits in mammals. Therefore, this study was conducted to evaluate significant associations between SNP of the STAT1 gene and milk production traits in buffaloes. Here, 18 SNP were identified in the buffalo STAT1 gene, including 15 intronic mutations and 3 exon mutations. All the identified SNP were then genotyped using matrix-assisted laser desorption/ionization time of flight mass spectrometry methods from 192 buffaloes. All the SNP were in Hardy-Weinberg equilibrium, and 2 haplotype blocks were successfully constructed based on these SNP data, which formed 5 and 3 major haplotypes in the population (>5%), respectively. The results of association analysis showed that only SNP13 located in exon 10 was significantly associated with the milk production traits in the population (P < 0.05). Single nucleotide polymorphism 2, SNP5, SNP8, and SNP9 were associated with protein percentage, and SNP4 and SNP10 were associated with 305-d milk yield (P < 0.05). Our results provide evidence that polymorphisms of the buffalo STAT1 gene are associated with milk production traits and can be used as a candidate gene for marker-assisted selection in buffalo breeding.

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