Characterization of a bla(CTX-M-3), bla(KPC-2) and bla(TEM-1B) co-producing IncN plasmid in Escherichia coli of chicken origin
文献类型: 外文期刊
作者: Wang Wen-jing 1 ; Wang Yi-fu 1 ; Jin Ya-jie 2 ; Song Wu-qiang 2 ; Lin Jia-meng 2 ; Zhang Yan 2 ; Tong Xin-ru 2 ; Tu Jian 1 ; Li Rui-chao 4 ; Li Tao 2 ;
作者机构: 1.Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
3.Guilin Med Univ, Guilin 541199, Peoples R China
4.Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China
关键词: bla(CTX-M-3); bla(KPC-2); bla(TEM-1B); IncN; plasmid; Escherichia coli
期刊名称:JOURNAL OF INTEGRATIVE AGRICULTURE ( 影响因子:4.8; 五年影响因子:4.8 )
ISSN: 2095-3119
年卷期: 2023 年 22 卷 1 期
页码:
收录情况: SCI
摘要: An extensively drug-resistant (XDR) Escherichia coli strain 258E was isolated from an anal swab sample of a chicken farm of Anhui Province in China. Genomic analyses indicated that the strain 258E harbors an incompatibility group N (IncN) plasmid pEC258-3, which co-produces bla(CTX-M-3), bla(KPC-2), bla(TEM-1B), qnrS1, aac(6 ')-Ib-cr, dfrA14, arr-3, and aac(6 ')-Ib3. Multiple genome arrangement analyses indicated that pEC258-3 is highly homologous with pCRKP-1-KPC discovered in Klebsiella pneumoniae from a patient. Furthermore, conjugation experiments proved that plasmid pEC258-3 can be transferred horizontally and may pose a significant potential threat in animals, community and hospital settings.
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