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From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human health

文献类型： 外文期刊

作者： Xie, Xiulan 1 ; Zhai, Yaohua 3 ; Cheng, Hao 1 ; Wei, Wen-Hua 4 ; Ren, Maozhi 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Urban Agr, Funct Plant Cultivat & Applicat Teams, Chengdu 610000, Peoples R China

2.State Key Lab Dao Di Herbs, Beijing 100700, Peoples R China

3.Zhengzhou Univ, Sch Agr Sci, State Key Lab Cotton Biol, Zhengzhou Res Base, Zhengzhou 450052, Peoples R China

4.Univ Manchester, Sch Hlth Sci, Ctr Biostat, Manchester M13 9PL, England

关键词： Adventitious roots; Paclitaxel biosynthesis; Synthesis strategy; Synthetic biology; Taxus x media; Urban agriculture

期刊名称：PLANT PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：5.7； 五年影响因子：6.4 ）

ISSN： 0981-9428

年卷期： 2025 年 220 卷

页码：

收录情况： SCI

摘要： Conifers of the genus Taxus are environmentally friendly plants with significant medicinal and ecological value, contributing to the enhancement of urban living environments. Paclitaxel, a compound found in Taxus, has garnered particular research interest owing to its potent anti-cancer effects. However, traditional methods of extracting paclitaxel from Taxus are not only inefficient, but also destructive and unsustainable, posing the major risk of Taxus extinction. To address this, sustainable production using modern biotechnology is crucial for the mass production of paclitaxel. Therefore, this review revisits the potential of Taxus and sustainable paclitaxel production in the context of urban agriculture. It provides a comprehensive review of widespread research efforts targeting efficient and cost-effective paclitaxel biosynthesis. We also discuss a set of innovative strategies for paclitaxel biosynthesis and suggest approaches for its industrial production based on Taxus cell-based approaches.

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