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Overexpression of a nuclear receptor HR96 contributes to spirodiclofen susceptibility in Panonychus citri (McGregor)

文献类型： 外文期刊

作者： Li, Si-chen 1 ; Cheng, Lu-yan 1 ; Yang, Qi-qi 1 ; Huang, Ze-hao 3 ; Shao, Bin-bin 1 ; Yu, Shi-jiang 1 ; Ding, Li-li 1 ; Pan, Qi 1 ; Lei, Shuang 1 ; Liu, Liu 1 ; Cong, Lin 1 ; Ran, Chun 1 ;

作者机构： 1.Southwest Univ, Citrus Res Inst, Chinese Acad Agr Sci, Natl Citrus Engn Res Ctr, Chongqing 400712, Peoples R China

2.Chongqing Inst Food & Drug Control, Key Lab Condiment Supervis Technol State Market Re, Chongqing 401121, Peoples R China

3.Sichuan Agr Univ, Coll Hort, Chengdu 611130, Peoples R China

关键词： Hormone receptor; Regulating resistance; Panonychus citri; Spirodiclofen

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 0048-3575

年卷期： 2024 年 202 卷

页码：

收录情况： SCI

摘要： The citrus red mite, Panonychus citri, is one of the most notorious and devastating citrus pests around the world that has developed resistance to multiple chemical acaricides. In previous research, we found that spirodiclofenresistant is related to overexpression of P450, CCE, and ABC transporter genes in P. citri . However, the regulatory mechanisms of these detoxification genes are still elusive. This study identified all hormone receptor 96 genes of P. citri . 8 PcHR96 genes contained highly conserved domains. The expression profiles showed that PcHR96h was significantly upregulated in spirodiclofen resistant strain and after exposure to spirodiclofen. RNA interference of PcHR96h decreased expression of detoxification genes and increased spirodiclofen susceptibility in P. citri . Furthermore, molecular docking, heterologous expression, and drug affinity responsive target stability demonstrated that PcHR96h can interact with spirodiclofen in vitro . Our research results indicate that PcHR96h plays an important role in regulating spirodiclofen susceptibility and provides theoretical support for the resistance management of P. citri.

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