文献类型： 外文期刊
作者： Qin, Shaogang 1 ; Chi, Xinyue 1 ; Zhu, Zijian 1 ; Chen, Chuanhe 2 ; Zhang, Tuo 3 ; He, Meina 3 ; Gao, Meng 1 ; Zhao, Ting 1 ; Zhang, Jingwen 1 ; Zhang, Lifan 4 ; Zheng, Wenying 1 ; Chen, Ziqi 1 ; Wang, Wenji 5 ; Zhou, Bo 1 ; Xia, Guoliang 1 ; Wang, Chao 1 ;
作者机构： 1.China Agr Univ, Coll Biol Sci, State Key Lab Farm Anim Biotech Breeding, Beijing, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
3.Guizhou Med Univ, Coll Basic Med, Dept Physiol, Guizhou Prov Key Lab Pathogenesis & Drug Res Commo, Guiyang, Guizhou, Peoples R China
4.Ningxia Univ, Coll Life Sci, Key Lab, Minist Educ Conservat & Utilizat Special Biol Res, Ningxia, Yinchuan, Peoples R China
5.Taizhou Univ, Sch Life Sci, Taizhou, Peoples R China
关键词： ferroptosis; primary ovarian insufficiency; primordial follicle; ROS; SOD1
期刊名称：AGING CELL （ 影响因子：7.1； 五年影响因子：8.9 ）
ISSN： 1474-9718
年卷期： 2025 年 24 卷 1 期
页码：
收录情况： SCI
摘要： Primordial follicles (PFs) function as the long-term reserve for female reproduction, remaining dormant in the ovaries and becoming progressively depleted with age. Oxidative stress plays an important role in promoting female reproductive senescence during aging, but the underlying mechanisms remain unclear. Here, we find that low levels of reactive oxygen species (ROS) are essential for sustaining PF dormancy. Compared to growing follicles, oocytes within PFs were shown to be more susceptible to ROS, which accumulates and damages PFs to promote reproductive senescence. Mechanistically, oocytes within PFs were shown to express high levels of the intracellular antioxidant enzyme superoxide dismutase 1 (SOD1), counteracting ROS accumulation. Decreased SOD1 expression, as a result of aging or through the experimental deletion of the Sod1 gene in oocytes, resulted in increased oxidative stress and triggered ferroptosis within PFs. In conclusion, this study identified antioxidant defense mechanisms protecting PFs in mouse ovaries and characterized cell death mechanisms of oxidative stress-induced PF death.
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