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Different Durations of Simulated Weightlessness Induced Depressive like Behaviors in Rats

文献类型： 外文期刊

作者： Zhang Mi-Jia 1 ; Wang Meng-Di 1 ; Ayaz, Ahmed 1 ; Dong Li 1 ; Yao Qin-Wei 4 ; Li Ying-Hui 5 ; Qu Li-Na 5 ; Chen Shan-Guang 6 ; Liu Xin-Min 1 ; Wang Qiong 1 ;

作者机构： 1.Southwest Med Univ, Sinoportugal TCM Int Cooperat Ctr, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Peoples R China

2.Chinese Acad Agr Sci CAAS, Inst Food Sci & Technol, Beijing 100193, Peoples R China

3.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Luzhou 646000, Peoples R China

4.Capital Med Univ, Beijing You An Hosp, Dept Crit Care Med Liver Dis, Beijing 100069, Peoples R China

5.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China

6.China Astronaut Res & Training Ctr, Natl Key Lab Human Factors Engn, Beijing 100094, Peoples R China

7.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing 100193, Peoples R China

8.Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

关键词： simulated weightlessness; depressive like behaviors; open field test; forced swim test; superoxide dismutase; catalase

期刊名称：PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS （ 影响因子：0.3； 五年影响因子：0.3 ）

ISSN： 1000-3282

年卷期： 2023 年 50 卷 2 期

页码：

收录情况： SCI

摘要： Objective This study was designed to observe different durations of simulated weightlessness induced depressive-like behaviors and the change of superoxide dismutase (SOD) and catalase (CAD in hippocampi of rats, so as to explore its effects and possible mechanism. Methods Weightlessness was simulated by hindlimb suspension by tails (HLS) in rats. The rats were divided into the control and the HLS groups for each respective week (s), i. e., 1, 2, 3, and 4. The depressive-like behaviors in rats were investigated by using the open field test (OFT), novel object recognition test (NORT), forced swim test (FST), followed by hippocampal protein level estimation of SOD and CAT by ELISA. Results The OFT results showed increased stagnation time among HLS rats in each respective group compared to their corresponding control groups (P<0.05, P<0.01). In the NORT, the latency of exploration increased, while the number and the time of exploration decreased in the HLS groups in each week, compared to their corresponding control rats (P<0.05, P<0.01). Similarly, FST displayed enhanced immobility with the reduced climbing rate in HLS rats in each respective week, compared to the normal rats (P<0.05, P<0.01). Simulated weightlessness significantly reduced the SOD and CAT levels in the hippocampi in HLS rats compared to the normal rats (P<0.05, P<0.01). Conclusion Results suggest that short or long weightlessness could induce depressive-like behaviors in rats.

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