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Whole-genome sequencing of multidrug-resistant Klebsiella pneumoniae with capsular serotype K2 isolates from mink in China

文献类型： 外文期刊

作者： Sun, Na 1 ; Yang, Yong 2 ; Wang, Guisheng 4 ; Guo, Li 1 ; Liu, Liming 1 ; San, Zhihao 1 ; Zhao, Cuiqing 1 ; Zhao, Lifeng 1 ; Tong, Mingwei 2 ; Cheng, Yuening 3 ; Chen, Qiang 1 ;

作者机构： 1.Jilin Agr Sci & Technol Univ, Coll Anim Sci & Technol, Jilin, Peoples R China

2.Shanxi Med Univ, Sch Basic Med Sci, Taiyuan, Peoples R China

3.Chinese Acad Agr Sci, Inst Special Econ Anim & Plants, Minist Agr, Key Lab Special Anim Epidem Dis, Changchun, Peoples R China

4.Shandong Prov Ctr Anim Dis Control & Prevent, Jinan, Peoples R China

关键词： Klebsiella pneumoniae; Mink; K2 serotype; Resistance genes; Virulence genes

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.3； 五年影响因子：2.6 ）

ISSN：

年卷期： 2024 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Background Klebsiella pneumoniae is a zoonotic opportunistic pathogen, and also one of the common pathogenic bacteria causing mink pneumonia. The aim of this study was to get a better understanding of the whole-genome of multi-drug resistant Klebsiella pneumoniae with K2 serotype in China. This study for the first time to analyze Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, resistance and virulence genes of Klebsiella pneumoniae in mink. Results The isolate was Klebsiella pneumoniae with serotype K2 and ST6189 by PCR method. The string test was positive and showed high mucus phenotype. There was one plasmid with IncFIB replicons in the genome. The virulence factors including capsule, lipopolysaccharide, adhesin, iron uptake system, urease, secretory system, regulatory gene (rcsA, rcsB), determinants of pili adhesion, enolase and magnesium ion absorption related genes. The strain was multi-drug resistant. A total of 26 resistance genes, including beta-lactam, aminoglycosides, tetracycline, fluoroquinolones, sulfonamides, amide alcohols, macrolides, rifampicin, fosfomycin, vancomycin, diaminopyrimidines and polymyxin. Multidrug-resistant efflux protein AcrA, AcrB, TolC, were predicted in the strain. Conclusion It was the first to identify that serotype K2 K. pneumonia with ST6189 isolated from mink in China. The finding indicated that hypervirulent and multi-drug resistant K. pneumoniae was exist in Chinese mink. The whole-genome of K. pneumoniae isolates have importance in mink farming practice.

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