Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum
文献类型： 外文期刊
作者： Zhang, Saixian 1 ; Xiang, Yue 2 ; Jian, Yaobang 2 ; Zhao, Qiulin 2 ; Sun, Jiahui 2 ; Huang, Yi 2 ; Xu, Jing 2 ; Qi, Xiaolong 1 ; Li, Jingjin 1 ; Zheng, Zhuqing 2 ; Fu, Liangliang 2 ; Liu, Yuwen 1 ; Li, Xinyun 2 ;
作者机构： 1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Key Lab Livestock, Shenzhen 518124, Peoples R China
2.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
3.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Swine Genet & Breeding, Minist Agr, Wuhan 430070, Peoples R China
关键词： feed efficiency; pigs; jejunum; RNA-seq; ATAC-seq; lipid metabolism; immune response
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2025 年 15 卷 2 期
页码：
收录情况： SCI
摘要： Feed efficiency (FE) is a crucial trait in pig production that influences both economic viability and environmental sustainability. The jejunum, an essential organ for nutrient absorption, plays a significant role in determining FE by affecting how pigs process and utilize feed. To explore the genetic and regulatory mechanisms behind FE, we conducted an integrative multi-omics study using RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) on pigs with high and low FE. By comparing gene expression and chromatin accessibility profiles in the jejunum, we identified key differentially expressed genes (DEGs) and differentially accessible regions (DARs) associated with lipid metabolism and immune function, both of which are critical pathways for efficient growth. Notably, we identified transcription factors such as GATA4 and EHF and genes like SCARB1 and GRXCR1 that may play regulatory roles in FE. Our findings provide novel insights into the molecular mechanisms governing FE in pigs, offering potential targets for genetic selection and nutritional interventions to enhance feed efficiency and sustainability in pig production.
- 相关文献
作者其他论文 更多>>
-
EXPERT expands prime editing efficiency and range of large fragment edits
作者：Xiong, Youcai;Su, Yinyu;He, Ruigao;Han, Xiaosong;Li, Sheng;Liu, Minghuan;Xi, Xiaoning;Liu, Zijia;Wang, Heng;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Ruan, Jinxue;Xiong, Youcai;Su, Yinyu;He, Ruigao;Han, Xiaosong;Li, Sheng;Liu, Minghuan;Xi, Xiaoning;Liu, Zijia;Wang, Heng;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Ruan, Jinxue;Han, Xiaosong;Zhao, Shuhong;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Li, Kui;Zhang, Jifeng;Xu, Jie
关键词：
-
Genome-Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells
作者：Zhu, Xiusheng;Huang, Lei;Li, Guoli;Deng, Biao;Wang, Xiaoxiao;Yang, Hu;Zhang, Yuanyuan;Wen, Qiuhan;Wang, Chao;Zhang, Jingshu;Li, Kui;Liu, Yuwen;Deng, Biao;Deng, Biao;Zhao, Yunxiang
关键词：
cis -regulatory elements; high-throughput; iPSCs; silencer; Ss-STARR-seq -
How the nutrient flow environment promotes lettuce growth in hydroponics
作者：Baiyin, Bateer;Xiang, Yue;Yang, Qichang;Shao, Yang;Son, Jung Eek;Tagawa, Kotaro;Yamada, Satoshi;Yamada, Mina
关键词：Antioxidant enzyme; Hydroponic cultivation; Lignin biosynthesis; Multi-Omics; Nutrient solution flow; Root morphology; Stress response; Urban agriculture
-
DPImpute: A Genotype Imputation Framework for Ultra-Low Coverage Whole-Genome Sequencing and its Application in Genomic Selection
作者：Zheng, Weigang;Wang, Chao;Dong, Wenjun;Liu, Yuwen;Zheng, Weigang;Wang, Chao;Dong, Wenjun;Liu, Yuwen;Zheng, Weigang;Ma, Wenlong;Chen, Zhilong;Wang, Chao;Sun, Tao;Dong, Wenjun;Zhang, Song;Tang, Zhonglin;Li, Kui;Liu, Yuwen;Zheng, Weigang;Ma, Wenlong;Chen, Zhilong;Wang, Chao;Sun, Tao;Dong, Wenjun;Zhang, Song;Tang, Zhonglin;Li, Kui;Liu, Yuwen;Zhang, Wenjing;Tang, Zhonglin;Liu, Yuwen;Zhao, Yunxiang
关键词：breeding models; genetic screening of embryos; genomic selection; genotype imputation; single cell genotype
-
Optimizing selenium-enriched yeast supplementation in laying hens: Enhancing egg quality, selenium concentration in eggs, antioxidant defense, and liver health
作者：Zhang, Longfei;Zhou, Jianmin;Obianwuna, Uchechukwu Edna;Qiu, Kai;Zhang, Haijun;Wu, Shugeng;Zhang, Longfei;Long, Cheng;Qi, Xiaolong
关键词：Antioxidant function; Laying hens; Liver health; Selenium-enriched yeast; Selenium-enriched eggs
-
SIMER: an accurate and intelligent tool for simulating customizable population data across species in complex scenarios
作者：Yin, Dong;Yin, Lilin;Tang, Zhenshuang;Xu, Jingya;Li, Xinyun;Zhao, Shuhong;Liu, Xiaolei;Yin, Dong;Zhao, Shuhong;Liu, Xiaolei;Yin, Dong;Yin, Lilin;Tang, Zhenshuang;Xu, Jingya;Li, Xinyun;Zhao, Shuhong;Liu, Xiaolei;Zhang, Xuanning;Zhang, Haohao;Yuan, Xiaohui;Zhou, Xiang;Zhou, Xiang;Zhao, Shuhong;Liu, Xiaolei;Liu, Xiaolei
关键词：Simulation; Breeding program; Genetic correlation; Linear mixed model (LMM); Repeated record trait; SIMER
-
Uncovering the whole genome silencers of human cells via Ss-STARR-seq
作者：Zhu, Xiusheng;Huang, Lei;Wang, Chao;Li, Guoli;Deng, Biao;Kong, Dashuai;Wang, Xiaoxiao;Chang, Rongrong;Gu, Yi;Wen, Qiuhan;Kong, Siyuan;Liu, Yuwen;Zhang, Yubo;Chang, Rongrong
关键词：
