文献类型： 外文期刊

作者： Feng, Cong ¹ ; Chen, Baizhi ¹ ; Hofer, Julie ² ; Shi, Yan ¹ ; Jiang, Mei ¹ ; Song, Bo ¹ ; Cheng, Hong ¹ ; Lu, Lu ¹ ; Wang, Luyao ¹ ; Howard, Alex ² ; Bendahmane, Abdel ³ ; Fouchal, Anissa ³ ; Moreau, Carol ² ; Sawada, Chie ² ; LeSignor, Christine ⁵ ; Zhang, Cuijun ¹ ; Vikeli, Eleni ² ; Tsanakas, Georgios ² ; Zhao, Hang ¹ ; Cheema, Jitender ² ; Barclay, J. Elaine ² ; Hou, Junliang ¹ ; Sayers, Liz ² ; Wingen, Luzie ² ; Vigouroux, Marielle ² ; Vickers, Martin ² ; Ambrose, Mike ² ; Dalmais, Marion ³ ; Higuera-Poveda, Paola ² ; Li, Pengfeng ¹ ; Yuan, Quan ¹ ; Spanner, Rebecca ² ; Horler, Richard ² ; Wouters, Roland ² ; Chundakkad, Smitha ² ; Wu, Tian ¹ ; Zhao, Xiaoxiao ¹ ; Li, Xiuli ¹ ; Sun, Yuchen ¹ ; Huang, Zejian ¹ ; Wu, Zhen ¹ ; Deng, Xing Wang ⁸ ; Steuernagel, Burkhard ² ; Domoney, Claire ² ; Ellis, Noel ² ; Chayut, Noam ² ; Cheng, Shifeng ¹ ;

作者机构： 1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Key Lab Synthet Biol,Minist Agr & Rural Affairs,Sh, Shenzhen, Peoples R China

2.John Innes Ctr, Norwich Res Pk, Norwich, England

3.Inst Plant Sci Paris Saclay, INRAE, UMR 1403, Gif Sur Yvette, France

4.INRAE Clermont Auvergne Rhone Alpes, Paleogen Lab, CS 60032, Clermont Ferrand, France

5.INRAE, Agroecol Pole GEAPSI, UMR1347, Dijon, France

6.European Mol Biol Lab, EMBL EBI, Wellcome Genome Campus, Hinxton, England

7.Univ Minnesota, Dept Plant Pathol, St Paul, MN USA

8.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Wheat Improvement, Beijing, Peoples R China

9.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Life Sci, Beijing, Peoples R China

期刊名称：NATURE （ 影响因子：48.5； 五年影响因子：55.0 ）

ISSN： 0028-0836

年卷期： 2025 年 642 卷 8069 期

页码：

收录情况： SCI

摘要： Mendel1 studied in detail seven pairs of contrasting traits in pea (Pisum sativum), establishing the foundational principles of genetic inheritance. Here we investigate the genetic architecture that underlies these traits and uncover previously undescribed alleles for the four characterized Mendelian genes2, 3, 4, 5, 6-7, including a rare revertant of Mendel's white-flowered a allele. Primarily, we focus on the three remaining uncharacterized traits and find that (1) an approximately 100-kb genomic deletion upstream of the Chlorophyll synthase (ChlG) gene disrupts chlorophyll biosynthesis through the generation of intergenic transcriptional fusion products, conferring the yellow pod phenotype of gp mutants; (2) a MYB gene with an upstream Ogre element insertion and a CLE peptide-encoding gene with an in-frame premature stop codon explain the v and p alleles, which disrupt secondary cell wall thickening and lignification, resulting in the parchmentless, edible-pod phenotype; and (3) a 5-bp exonic deletion in a CIK-like co-receptor kinase gene, in combination with a genetic modifier locus, is associated with the fasciated stem (fa) phenotype. Furthermore, we characterize genes and alleles associated with diverse agronomic traits, such as axil ring anthocyanin pigmentation, seed size and the 'semi-leafless' form. This study establishes a foundation for fundamental research, education in biology and genetics, and pea breeding practices.