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High histone crotonylation modification in bovine fibroblasts promotes cell proliferation and the developmental efficiency of preimplantation nuclear transfer embryos

文献类型： 外文期刊

作者： Zhao, Xiaoyu 1 ; Du, Mengxin 1 ; Wu, Shanshan 1 ; Du, Zhiwen 1 ; Liu, Shuqin 1 ; Yang, Lei 1 ; Ma, Haoran 4 ; Zhang, Liguo 5 ; Song, Lishuang 1 ; Bai, Chunling 1 ; Su, Guanghua 1 ; Li, Guangpeng 1 ;

作者机构： 1.Inner Mongolia Univ, State Key Lab Reprod Regulat & Breeding Grassland, 24 Zhaojun Rd, Hohhot 010070, Peoples R China

2.Inner Mongolia Univ, Coll Life Sci, 24 Zhaojun Rd, Hohhot 010070, Peoples R China

3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518000, Peoples R China

4.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

5.Ulanqab Anim Husb Workstn, Ulanqab Agr & Anim Husb Bur, Ulanqab 012000, Inner Mongolia, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN： 2045-2322

年卷期： 2024 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Lysine crotonylation (Kcr) is a recently discovered histone acylation modification that is closely associated with gene expression, cell proliferation, and the maintenance of stem cell pluripotency and indicates the transcriptional activity of genes and the regulation of various biological processes. During cell culture, the introduction of exogenous croconic acid disodium salt (Nacr) has been shown to modulate intracellular Kcr levels. Although research on Kcr has increased, its role in cell growth and proliferation and its potential regulatory mechanisms remain unclear compared to those of histone methylation and acetylation. Our investigation demonstrated that the addition of 5 mM Nacr to cultured bovine fibroblasts increased the expression of genes associated with Kcr modification, ultimately promoting cell growth and stimulating cell proliferation. Somatic cell nuclear transfer of donor cells cultured in 5 mM Nacr resulted in 38.1% blastocyst development, which was significantly greater than that in the control group (25.2%). This research is important for elucidating the crotonylation modification mechanism in fibroblast proliferation to promote the efficacy of somatic cell nuclear transfer.

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