Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis
文献类型： 外文期刊
作者： Luan, Ning 1 ; Zuo, Junli 1 ; Niu, Qianping 1 ; Yan, Wei 2 ; Hung, Tien-Chieh 3 ; Liu, Haoling 1 ; Wu, Qin 4 ; Wang, Guoao 1 ; Deng, Ping 5 ; Ma, Xufa 1 ; Qin, Jianhui 1 ; Li, Guangyu 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Hubei Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Hubei Key Lab Nutr Qual & Safety Agroprod, Wuhan 430064, Hubei, Peoples R China
3.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA
4.Hubei Normal Univ, Hubei Key Lab Edible Wild Plants Conservat & Utili, Huangshi Key Lab Lake Biodivers & Environm Conserv, Huangshi 435002, Hubei, Peoples R China
5.Wuhan Acad Agr Sci, Study & Pract Demonstratiministryon Regime Shifts, Wuhan 430056, Peoples R China
关键词： MCLR; Probiotic; Neurotransmitter; Gut-brain axis; HPI axis
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）
ISSN： 0048-9697
年卷期： 2024 年 908 卷
页码：
收录情况： SCI
摘要： Microcystin-LR (MCLR) is one of the most toxic cyanobacterial toxins and is harmful to the central nervous system of fish. Probiotic additives can improve neuroendocrine function in fish. Although both MCLR and probiotics aim at the nervous system, whether they interact with each other and the mechanisms remain un-explored. In the present study, 4-month-old zebrafish were exposed to 0, 2.2, and 22 mu g/L of MCLR for 28 days with or without the probiotic L. rhamnosus. We found that MCLR exposure could inhibit the swimming speed of zebrafish, while the presence of L. rhamnosus mitigated this abnormality. To elucidate the mechanism of how L. rhamnosus alleviates MCLR-induced neurotoxicity, we examined the bioaccumulation of MCLR, changes in neurotransmitters, immune biochemical indicators, and hormone content of the hypothalamic-pituitary-interrenal (HPI) axis in zebrafish along the gut-brain axis. Our results showed L. rhamnosus could reverse the abnormal swimming behavior and eventually alleviate neurotoxicity in zebrafish by modulating intestinal and brain neural signaling, neuroinflammation, and HPI axis responses. This study provides implications for the application of probiotics in the aquaculture industry.
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