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Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development

文献类型： 外文期刊

作者： Wang, Lewen 1 ; Ying, Yaqi 1 ; Li, Ning 1 ; Song, Ying 1 ; Zhao, Lijuan 3 ; Sun, Hong 3 ; Wang, Zhenlong 3 ; Liu, Xiao-Hui 1 ; Wang, Dawei 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China

2.Chinese Acad Agr Sci, Western Agr Res Ctr, Changji 831100, Xinjiang Uygur, Peoples R China

3.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China

关键词： Photoperiod; Hypothalamus; Testicular development; Brandt's vole; Transcriptome

期刊名称：FUNCTIONAL & INTEGRATIVE GENOMICS （ 影响因子：3.1； 五年影响因子：3.0 ）

ISSN： 1438-793X

年卷期： 2025 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Postnatal gonadal development is regulated by photoperiod via the hypothalamus, especially in seasonal breeding small rodents. However, the precise molecular mechanisms remain unclear. In this study, we conducted a comparative analysis of the transcriptomes of the hypothalamus and testes in 10-week-old male Brandt's voles born under long (LP, 16L:8D) and short photoperiod (SP, 8L:16D) conditions. Results indicate that the SP group exhibited significantly smaller testes with spermatogenesis halted before meiosis, identifying 129 differentially expressed genes (DEGs) in the hypothalamus and 21,673 DEGs in the testes. In the hypothalamus, genes involved in the thyroid hormone and retinoic acid (RA) pathway were notably altered under SP conditions, including decreased Tshb and Cga expression, increased Dio3, and reduced Crabp1 and Lrat, highlighting their key roles in SP signaling. In the testes, downregulated genes were significantly enriched in male reproduction-related GO terms and metabolic KEGG pathways, such as steroid hormone biosynthesis and retinol metabolism. Key genes for testosterone synthesis (e.g. Star, Cyp11a1) and RA synthesis (e.g. Rdh10, Rdh11) were downregulated, while those linked to RA degradation (Cyp26b1) and undifferentiated spermatogonia maintenance (e.g. Gdnf, Gfra1) were upregulated. These findings outline a molecular microenvironment that favors the preservation of undifferentiated spermatogonia over their differentiation from the hypothalamus to the testes. This study firstly provides valuable insights into the transcriptomic basis of SP-inhibited testicular development in Brandt's voles.

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