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Antigenic Characterization of Infectious Bronchitis Virus in the South China during 2021-2022

文献类型： 外文期刊

作者： Yuan, Weifeng 1 ; Lv, Ting 1 ; Jiang, Weiwei 1 ; Hou, Yuechi 1 ; Wang, Qingyi 1 ; Ren, Jinlian 1 ; Fan, Lei 1 ; Xiang, Bin 5 ; Lin, Qiuyan 1 ; Ding, Chan 6 ; Ren, Tao 1 ; Chen, Libin 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

2.Natl & Reg Joint Engn Lab Medicament Zoonosis Prev, Guangzhou 510642, Peoples R China

3.Minist Agr, Key Lab Anim Vaccine Dev, Guangzhou 510642, Peoples R China

4.Key Lab Zoonosis Prevent & Control Guangdong Prov, Guangzhou 510642, Peoples R China

5.Yunnan Agr Univ, Coll Vet Med, Kunming 650201, Peoples R China

6.Chinese Acad Agr Sci CAAS, Shanghai Vet Res Inst SHVRI, Shanghai 200241, Peoples R China

关键词： infectious bronchitis virus; chicken coronavirus; antigenic characterization; molecular evolution

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 6 期

页码：

收录情况： SCI

摘要： Avian infectious bronchitis is a serious and highly contagious disease that is caused by the infectious bronchitis virus (IBV). From January 2021 to June 2022, 1008 chicken tissue samples were collected from various regions of southern China, and 15 strains of the IBV were isolated. Phylogenetic analysis revealed that the strains mainly comprised the QX type, belonging to the same genotype as the currently prevalent LX4 type, and identified four recombination events in the S1 gene, among which lineages GI-13 and GI-19 were most frequently involved in recombination. Further study of seven selected isolates revealed that they caused respiratory symptoms, including coughing, sneezing, nasal discharge, and tracheal sounds, accompanied by depression. Inoculation of chicken embryos with the seven isolates resulted in symptoms such as curling, weakness, and bleeding. Immunization of specific pathogen-free (SPF) chickens with inactivated isolates produced high antibody levels that neutralized the corresponding strains; however, antibodies produced by vaccine strains were not effective in neutralizing the isolates. No unambiguous association was found between IBV genotypes and serotypes. In summary, a new trend in IBV prevalence has emerged in southern China, and currently available vaccines do not provide protection against the prevalent IBV strains in this region, facilitating the continued spread of IBV.

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