文献类型： 外文期刊
作者： Yang, Bowen 1 ; Li, Zilong 3 ; Zhang, Jingyu 1 ; Qiu, Shiwen 3 ; Liu, Xueting 1 ; Liang, Zonglin 3 ; Yan, Hao 3 ; Zhang, Yanyan 5 ; Liu, Lihong 6 ; Xia, Bing 6 ; Bao, Lianqun 6 ; Li, Defeng 3 ; Zhou, Shanshan 3 ; Corre, Christophe 7 ; Zhang, Chengyu 1 ; Lu, Yinhua 8 ; Tan, Gao-Yi 1 ; Xia, Xuekui 9 ; Li, Shanshan 5 ; Zhang, Lixin 1 ; Wang, Weishan 1 ;
作者机构： 1.East China Univ Sci & Technol ECUST, State Key Lab Bioreactor Engn, Shanghai, Peoples R China
2.East China Univ Sci & Technol ECUST, Sch Biotechnol, Shanghai, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Divers & Innovat Utilizat, Beijing, Peoples R China
4.Beijing Key Lab Genet Element Biosourcing & Intell, Beijing, Peoples R China
5.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China
6.Hebei Xingbai Agrochem Grp Co Ltd, Shijiazhuang, Peoples R China
7.Univ Warwick, Sch Life Sci, Coventry, England
8.Shanghai Normal Univ, Coll Life Sci, Shanghai, Peoples R China
9.Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan, Peoples R China
10.Shanghai Collaborat Innovat Ctr Biomfg Technol SCI, Shanghai, Peoples R China
11.Univ Chinese Acad Sci, Beijing, Peoples R China
期刊名称：NATURE BIOTECHNOLOGY （ 影响因子：41.7； 五年影响因子：59.5 ）
ISSN： 1087-0156
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Streptomyces species are producers of bioactive secondary metabolites with clinical, agricultural and biotechnological applications. To scale these strains for industrial production, a plug-and-play system that orchestrates multitarget engineering for maximizing cellular contributions to secondary metabolites is needed. Building on the discovery that distinct quorum-sensing receptors within the Streptomyces genus can recognize an identical DNA-binding site, we build a quorum-sensing-triggered promoter applicable across various Streptomyces. Integrating this promoter with a stabilizer and a multiplexer module, we develop a Streptomyces multiplexed artificial control system (SMARTS) that converts the transient signals of diverse quorum sensing into stable and multiplexed on or off outputs with varying strengths. We build a redesigned native Streptomyces avermitilis for specialized production of the nematicide baiweimectin and a de novo programmed Streptomyces venezuelae for heterologous production of the semisynthesized antitumor drug epidoxorubicin. Notably, the baiweimectin-producing strain was scaled up to a 120-m3 industrial-scale fermentation with a titer of 8.4 g L-1, underscoring the robustness of the SMARTS-based program.
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