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LAZARUS 1 functions as a positive regulator of plant immunity and systemic acquired resistance

文献类型： 外文期刊

作者： Chen, Yue 1 ; Han, Yue 1 ; Huang, Weijie 3 ; Zhang, Yanjun 4 ; Chen, Xiaoli 1 ; Li, Dongyue 1 ; Hong, Yi 1 ; Gao, Huhu 1 ; Zhang, Kewei 4 ; Zhang, Yuelin 5 ; Sun, Tongjun 1 ;

作者机构： 1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Shenzhen, Peoples R China

2.Chinese Acad Agr Sci, Genome Anal Lab, Minist Agr & Rural Affairs, Agr Genom Inst Shenzhen, Shenzhen, Peoples R China

3.Univ British Columbia, Dept Bot, Vancouver, BC, Canada

4.Zhejiang Normal Univ, Coll Life Sci, Zhejiang Prov Key Lab Biotechnol Specialty Econ Pl, Jinhua, Zhejiang, Peoples R China

5.Sichuan Univ, Coll Life Sci, Key Lab Bioresource & Eco Environm, Minist Educ, Chengdu, Peoples R China

关键词： salicylic acid; N-hydroxypipecolic acid; CBP60g; SARD1; LAZ1

期刊名称：FRONTIERS IN PLANT SCIENCE （ 影响因子：4.8； 五年影响因子：5.7 ）

ISSN： 1664-462X

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Systemic acquired resistance (SAR) is activated by local infection and confers enhanced resistance against subsequent pathogen invasion. Salicylic acid (SA) and N-hydroxypipecolic acid (NHP) are two key signaling molecules in SAR and their levels accumulate during SAR activation. Two members of plant-specific Calmodulin-Binding Protein 60 (CBP60) transcription factor family, CBP60g and SARD1, regulate the expression of biosynthetic genes of SA and NHP. CBP60g and SARD1 function as master regulators of plant immunity and their expression levels are tightly controlled. Although there are numerous reports on regulation of their expression, the specific mechanisms by which SARD1 and CBP60g respond to pathogen infection are not yet fully understood. This study identifies and characterizes the role of the LAZARUS 1 (LAZ1) and its homolog LAZ1H1 in plant immunity. A forward genetic screen was conducted in the sard1-1 mutant background to identify mutants with enhanced SAR-deficient phenotypes (sard mutants), leading to the discovery of sard6-1, which maps to the LAZ1 gene. LAZ1 and its homolog LAZ1H1 were found to be positive regulators of SAR through regulating the expression of CBP60g and SARD1 as well as biosynthetic genes of SA and NHP. Furthermore, Overexpression of LAZ1, LAZ1H1 and its homologs from Nicotiana benthamiana and potato enhanced resistance in N. benthamiana against Phytophthora pathogens. These findings indicate that LAZ1 and LAZ1H1 are evolutionarily conserved proteins that play critical roles in plant immunity.

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