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Simultaneous determination of antibiotics and amantadines in animal-derived feedstuffs by ultraperformance liquid chromatographic-tandem mass spectrometry

文献类型： 外文期刊

作者： Suo Decheng 1 ; Wang Peilong 1 ; Li Yang 1 ; Wang Ruiguo 1 ; Wei Shulin 1 ; Xiao Zhiming 1 ; Zhang Su 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agr Prod, Beijing 100081, Peoples R China

关键词： Ultraperformance liquid chromatography-tandem mass spectrometry; Antibiotics; Amantadines; Animal-derived feedstuffs

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

ISSN： 1570-0232

年卷期： 2018 年 1095 卷

页码：

收录情况： SCI

摘要： In this study, a method for simultaneous determination of 40 antibiotics from 6 different drug families (7 quinolones, 5 penicillins, 8 macrolides, 2 lincosamides, 4 tetracyclines, and 13 sulfonamides) and 3 amantadines in animal-derived feedstuffs (ADF) through ultraperformance liquid chromatography-tandem mass spectrometry using a new lipid-removing solid-phase extraction column PRiME HLB was developed. The sample was extracted with 20 mL extraction solution and then purified and concentrated with PRiME HLB. The eluent was evaporated to dryness under nitrogen and analyzed with LC-MS/MS using acetonitrile and 0.1% formic acid as the mobile phase via gradient elution. Under the optimum conditions, recoveries were 65.8% to 104.4% with a relative standard deviation of < 15% at spiked levels of 5.0 mu g/kg to 100 mu g/kg. The limits of detection ranged from 0.5 mu g/kg to 5 mu g/kg. 15 of the 43 drugs were found in ADF. Sulfonamides, fluoroquinolones, macrolides, tetracyclines, and amantadines were detected, with the highest levels reaching 325 mu g/kg.

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