A genome-wide association study suggests several novel candidate genes for carcass traits in Chinese Simmental beef cattle
文献类型： 外文期刊
作者： Chang, T. 1 ; Xia, J. 1 ; Xu, L. 1 ; Wang, X. 1 ; Zhu, B. 1 ; Zhang, L. 1 ; Gao, X. 1 ; Chen, Y. 1 ; Li, J. 1 ; Gao, H. 1 ;
作者机构： 1.Chinese Acad Agr Sci, Lab Mol Biol & Bovine Breeding, Inst Anim Sci, Beijing 100193, Peoples R China
关键词： bone weight; carcass weight; CIM polygene model; GWAS; linear mixed model
期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）
ISSN： 0268-9146
年卷期： 2018 年 49 卷 4 期
页码：
收录情况： SCI
摘要： A genome-wide association study (GWAS) was conducted for two carcass traits in Chinese Simmental beef cattle. The experimental population consisted of 1301 individuals genotyped with the Illumina BovineHD SNP BeadChip (770K). After quality control, 671990 SNPs and 1217 individuals were retained for the GWAS. The phenotypic traits included carcass weight and bone weight, which were measured after the cattle were slaughtered at 16 to 18months of age. Three statistical modelsa fixed polygene model, a random polygene model and a composite interval mapping polygene modelwere used for the GWAS. The genome-wide significance threshold after Bonferroni correction was 7.44E-08 (=0.05/671990). In this study, we detected eight and seven SNPs significantly associated with carcass weight and bone weight respectively. In total, 11 candidate genes were identified within or close to these significant SNPs. Of these, we found several novel candidate genes, including PBX1, GCNT4, ALDH1A2, LCORL and WDFY3, to be associated with carcass weight and bone weight in Chinese Simmental beef cattle, and their functional roles need to be verified in further studies.
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