Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response
文献类型： 外文期刊
作者： Zhu, L. 1 ; Wang, P. 1 ; Yuan, W. 3 ; Zhu, G. 1 ;
作者机构： 1.Yangzhou Univ, Coll Vet Med, 48 East Wenhui Rd, Yangzhou 225009, Jiangsu, Peoples R China
2.Jiangsu Coinnovat Ctr Prevent & Control Important, 48 East Wenhui Rd, Yangzhou 225009, Jiangsu, Peoples R China
3.Chinese Acad Agr Sci, Inst Anim Sci, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China
关键词： BoHV-1; inflammation; Kaempferol; cytokine
期刊名称：ACTA VIROLOGICA （ 影响因子：1.162； 五年影响因子：1.255 ）
ISSN： 0001-723X
年卷期： 2018 年 62 卷 2 期
页码：
收录情况： SCI
摘要： Plant-derived flavonoids contain large amount of compounds with pharmacological effects. In this study, we showed the compound Kaempferol to have robust antiviral activity against bovine herpesvirus 1 (BoHV-1) replication in vitro. Kaempferol at a concentration of 100 mu mol/l completely inhibited viral replication in MDBK cells. It mainly affects the viral replication at the post-entry stages. The inhibition of Akt signaling is a potential mechanism underlying the antiviral effect of Kaempferol. In addition, at a concentration of 25 and 50 mu mol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1 alpha) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation. Overall, our results indicated that Kaempferol provides a potent protection against BoHV-1 infection and LPS-induced inflammatory response.
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