Structural characterization and cardioprotective activities of natural polysaccharides from Apocynum venetum L
文献类型： 外文期刊
作者： Xie, Wenli 1 ; Xia, Qing 2 ; Xu, Zongchang 4 ; Xu, Kuo 1 ; Fu, Xianjun 1 ;
作者机构： 1.Shandong Univ Tradit Chinese Med, Res Inst Marine Tradit Chinese Med, Key Lab Marine Tradit Chinese Med Shandong Univ, SATCMs Key Unit Discovering & Developing New Marin, Jinan 250355, Peoples R China
2.Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250103, Peoples R China
3.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao Key Technol Innovat Ctr Marine Tradit Chin, Qingdao Key Lab Res Marine Tradit Chinese Med, Qingdao 266114, Peoples R China
4.Chinese Acad Agr Sci, Tobacco Res Inst, Marine Agr Res Ctr, Qingdao 266101, Peoples R China
5.Natl Ctr Technol Innovat Comprehens Utilizat Salin, Dongying 257345, Peoples R China
关键词：
期刊名称：CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE （ 影响因子：5.2； 五年影响因子：6.1 ）
ISSN：
年卷期： 2025 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Apocynum venetum L. represents a species with medicinal-food homology that is utilized in the management of hypertension and is widely consumed as a health-promoting tea in East Asia. This study reports the identification and characterization of two novel polysaccharides (PSs), AV1-N1 and AV2-N1, extracted from A. venetum L. The PSs were purified with a DEAE Seplife FF an ion exchange column and a Sephacryl S-400HR gel column and characterized by monosaccharide composition, FT-IR spectroscopy, methylation, and NMR spectroscopic analyses. It was determined that AV1-N1 and AV2-N1 were primarily composed of arabinose and galactose in varying proportions, with average molecular weights of 64.1 kDa and 58.8 kDa, respectively. The primary structure of both AV1-N1 and AV2-N1 predominantly comprises the R -> 6)-beta-D-Galp (1 -> R) unit, featuring alpha-L-Araf (1 -> R) branches at the C-3 position. Both AV1-N1 and AV2-N1 possess a reducing end characterized by the R -> 3,6)-beta-D-Galp (1 -> R) unit and share identical nonreducing ends, specifically the R -> 5)-alpha-L-Araf (1 -> R) residue. In addition, this study provides the first comprehensive evaluation of the cardioprotective activities of A. venetum L. PSs, demonstrating significant protective effects against DOX-induced heart failure. Notably, at identical concentrations, AV2-N1 demonstrates more pronounced therapeutic efficacy than AV1-N1 across evaluation indicators including pericardial edema area, heart rate, ejection fraction, and cardiac output. It is postulated that AV2-N1 may enhance ampk, pgc-1 alpha, nrf2, gpx4a, ho-1, and prdx1 gene expression, thereby effectively inhibiting reactive oxygen species (ROS) production and mitigating oxidative damage, ultimately exerting cardioprotective effects. These findings hold significant promise for the further development and utilization of A. venetum L. PSs.
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