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Synbiotic combination of 2′-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid

文献类型： 外文期刊

作者： He, Ying 1 ; Zhang, Bo 1 ; Xin, Yu 1 ; Wang, Wenxiu 1 ; Wang, Xue 1 ; Liu, Zhuo 1 ; She, Yongbo 1 ; Guo, Rui 1 ; Jia, Gengjie 5 ; Wu, Shan 3 ; Liu, Zhigang 1 ;

作者机构： 1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Peoples R China

2.Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Guangdong, Peoples R China

3.Xian Yinqiao Dairy Grp Co Ltd, Res & Dev Ctr, Xian 710075, Shaanxi, Peoples R China

4.Shaanxi Precis Nutr & Hlth Res Inst, Xian 710300, Peoples R China

5.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Genome Anal Lab, Minist Agr & Rural Affairs, Shenzhen 518120, Peoples R China

期刊名称：FOOD & FUNCTION （ 影响因子：5.4； 五年影响因子：6.1 ）

ISSN： 2042-6496

年卷期： 2025 年 16 卷 7 期

页码：

收录情况： SCI

摘要： Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disorders characterized by social deficits and repetitive behaviors. Increasing evidence suggests that the gut microbiota influences neurodevelopment and behavior. In this study, we established an ASD model by administering valproic acid (VPA) to pregnant females, with male offspring receiving a daily synbiotic intervention for four weeks post-weaning. The results indicate that the synbiotic combination of 2 '-Fucosyllactose (2 '-FL) and Bifidobacterium animalis subsp. lactis BB-12 (BB-12) outperformed that of 2 '-FL and Lactobacillus paracasei L9300BH (L9300BH) in alleviating social deficits, repetitive behaviors, neuronal damage, and dysregulated expression of social-related genes and neuroinflammatory markers in ASD mice. Additionally, the intervention with 2 '-FL and BB-12 improved gut morphology and barrier integrity, reduced gut inflammation, and optimized the gut microbiota structure by increasing the abundance of Bifidobacteria and Akkermansia, known producers of short-chain fatty acids (SCFAs). Notably, levels of acetate, propionate, and butyrate were significantly elevated in fecal samples. In summary, the synbiotic combination of 2 '-FL and BB-12 supports gut microbiota homeostasis, enhances fecal SCFA levels, and mitigates neurodevelopmental abnormalities in ASD mice.

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