您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

(3-Cyclodextrin/cationic-cellulose/naringenin complex-stabilized Pickering lemon emulsions with enhanced bioavailability

文献类型： 外文期刊

作者： Liu, Ting 1 ; Chen, Yuying 1 ; Wang, Yanqi 1 ; Wang, Xueping 1 ; Zheng, Jinkai 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China

2.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

3.Wageningen Univ & Res, Human & Anim Physiol, NL-6708 WD Wageningen, Netherlands

4.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao 266109, Peoples R China

关键词： Pickering emulsion; Encapsulation; Release; Bioaccessibility; Bioavailability

期刊名称：FOOD HYDROCOLLOIDS （ 影响因子：12.4； 五年影响因子：13.3 ）

ISSN： 0268-005X

年卷期： 2025 年 166 卷

页码：

收录情况： SCI

摘要： A low loading capacity and gastrointestinal instability are critical issues that need to be addressed to improve the bioavailability of conventional Pickering emulsions (CPEs). Using naringenin, a citrus-derived bioactive compound with multiple health-promoting effects as an example, this study developed a novel (3-cyclodextrin/ cationic cellulose/naringenin complex ((3-CD/C-CNC/Nar) as an emulsifier to construct a novel Pickering emulsion (NPE), in which naringenin is present in the complex at the oil-water interface; this is distinct from a CPE that loads naringenin in the oil phase. The loading capacity (0.9 mg/mL) of the NPE was increased at least 10 times compared to the CPE. The 24-h apparent stability, centrifugal stability, and thermal stability of the NPE was improved after dissolving LMP, a natural polysaccharide that enhances emulsion stability by increasing the viscosity, which could form a three-dimensional network through hydrogen bonding interactions at a lower pH. In vitro simulated digestion showed that the NPE with 2 wt% LMP effectively resisted digestive environment stress, especially in the gastric phase, and significantly improved the bioaccessibility (41.01%) and naringenin release percentage (44.0%). In vivo pharmacokinetic tests demonstrated that the NPE with 2 wt% LMP had excellent bioavailability (Cmax 0.27 mu g/mL, AUC0 -> 24 9.56 h mu g/mL) and sustained-release effect (Tmax 2 h). This study provides new insights into the development of flavor NPEs for the efficient in vivo delivery of hydrophobic bioactive compounds.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台