文献类型： 外文期刊
作者： Chang, Babar Hussain 1 ; Qiang, Bian 4 ; Li, Shuang 1 ; Ullah, Hidayat 1 ; Hao, Kun 1 ; McNeill, Mark Richard 7 ; Rajp 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
2.Linyi Univ, Coll Agr & Forestry Sci, Linyi 276000, Shandong, Peoples R China
3.Minist Agr & Rural Affairs, Sci Observat & Expt Stn Pests Xilin Got Rangeland, Xilinhot 026000, Peoples R China
4.Nankai Univ, Natl Pesticide Engn Res Ctr, Tianjin 300071, Peoples R China
5.Sindh Agr Univ, Dept Entomol, Tandojam 70060, Sindh, Pakistan
6.Univ Swabi, Dept Agr, Swabi 23561, Khyber Pakhtunk, Pakistan
7.AgResearch Ltd, Lincoln Res Ctr, Christchurch 8140, New Zealand
关键词： Inhibitors; Grasshopper; Performance; Gene; Insulin-like signaling pathway; Protective enzyme
期刊名称：ARTHROPOD-PLANT INTERACTIONS （ 影响因子：1.988； 五年影响因子：2.059 ）
ISSN： 1872-8855
年卷期：
页码：
收录情况： SCI
摘要： Protein tyrosine kinase (PTKs) and protein tyrosine phosphatase (PTPs) collectively regulate the insect insulin-signaling pathway (ISP), cell growth, metabolism, proliferation, differentiation, cell communication and monitoring of immune responses. We studied the inhibitory response of the grasshopper Oedaleus asiaticus Bey-Bienko to treat with the flavonoid genistein (PTK inhibitor), the enzyme PTP1B-IN-1 (PTP1B inhibitor) and control (dimethyl sulfoxide (DMSO)). Mean survival rates were not significantly different amongst the three treatments, but growth rate, body mass, and overall biological performance were reduced significantly following treatment with genistein. On comparison, treatment with PTP1B-IN-1 was not significantly different from the control. Relative gene expression of INSR, IRS, PI3K, PDK, and Akt was substantially lower (P < 0.05) following treatment with genistein compared to PTP1B-IN-1 and control. Similarly, gene expression and protein phosphorylation levels of the PTK5, PTP1B -> FOXO cascade, indicators of stress response in the ISP, were also reduced in response to genistein treatments. The activity of the protective enzymes (POD and CAT) was upregulated by FOXO in response to PTP1B-IN-1. Our results demonstrated that genistein negatively regulates the ISP pathway, with a consequent effect on growth and development of O. asiaticus, as higher energy was required for detoxification. Given the negative effect of genistein on O. asiaticus physiology and development, the compound could be used in a biopesticide formulation for insect pest control in grasslands and other crop plants as a potential application to grasshopper biological control.
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