Insecticide and pathogens co-exposure induces histomorphology changes in midgut and energy metabolism disorders on Apis mellifera
文献类型： 外文期刊
作者： Kang, Yuxin 1 ; Guo, Junxiu 1 ; Wu, Tong 1 ; Han, Bo 1 ; Liu, Feng 3 ; Chu, Yu 1 ; Wang, Qiang 1 ; Gao, Jing 1 ; Dai, Pingli 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Apicultural Res, State Key Lab Resource Insects, Beijing 100193, Peoples R China
2.Beijing Univ Agr, Coll Biosci & Resources Environm, Key Lab Northern Urban Agr, Minist Agr & Rural Affairs, Beijing 102206, Peoples R China
3.Jiangxi Inst Apicultural Res, Nanchang 330201, Peoples R China
关键词： Honey bees; Ecotoxicology; Pesticide; Pathogens; Combined effects
期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.0； 五年影响因子：4.5 ）
ISSN： 0048-3575
年卷期： 2025 年 211 卷
页码：
收录情况： SCI
摘要： Honey bees in agroecosystems face increasingly exposure to multiple stressors, such as pesticides and pathogens, making it crucial to assess their combined impacts rather than focusing on individual factors alone. This study examined the adverse effects of single exposure acetamiprid, Varroa destructor, and Nosema ceranae, both individually and in combination, on honey bee survival, midgut integrity and transcriptomic changes to understand the molecular mechanisms involved. The findings revealed that combination of acetamiprid and N. ceranae induced significant energetic stress, as evidenced by disruptions in energy metabolism. The synergistic effects of V. destructor and N. ceranae led to severe alterations in midgut histomorphology, particularly damaging the midgut epithelium. Concurrent exposure to acetamiprid and V. destructor inhibited the immune response and energy metabolism of honey bees, thereby exacerbating the vulnerability to pathogens and destabilizing their physiological equilibrium. The combination of all three stressors caused the most dramatic damage, disrupting midgut structure as well as aromatic amino acids and lipid metabolism. Our study underscored the complexity and unpredictability of stressor interactions, emphasizing the need to consider environmental context when assessing the risks of honey bee health.
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