Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways
文献类型： 外文期刊
作者： Sha, Ji-yue 1 ; Chen, Ke-Cheng 2 ; Liu, Zheng-bo 1 ; Li, Wei 3 ; Lu, Yu-shun 1 ; Liu, Shuang 4 ; Ma, Jian-kai 5 ; Qu, Di 1 ; Sun, Yin-shi 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, Changchun 130112, Jilin, Peoples R China
2.Goldenwell Biotech Inc, Reno, NV 89501 USA
3.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
4.Looking 9 Starry Sky Med Res Ctr, Siping 136000, Peoples R China
5.Baker Jilin Special Med Hlth Ind Co Ltd, Changchun 130102, Peoples R China
关键词： Ginseng-DF; CTX; Immunosuppression; Intestinal mucosal barrier injury; MAPK/NF-kappa B signaling pathway
期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：5.0； 五年影响因子：5.2 ）
ISSN： 1436-6207
年卷期： 2024 年
页码：
收录情况： SCI
摘要： PurposeDietary fiber (DF) has a good application prospect in effectively restoring the integrity of the intestinal mucosal barrier. Ginseng-DF has good physicochemical properties and physiological activity and shows positive effects in enhancing immunity. The aim of this study was to investigate the protective effect of Ginseng-DF on intestinal mucosal barrier injury induced by cyclophosphamide (CTX) in immunosuppressed mice and its possible mechanism.MethodsThe effects of Gginseng-DF on immune function in mice were studied by delayed-type hypersensitivy, lymphocyte proliferation assay and NK cytotoxicity assay, the T lymphocyte differentiation and intestinal barrier integrity were analyzed by flow cytometry and western blot.ResultsGinseng-DF (2.5% and 5%) could attenuate the inhibition of DTH response by CTX, promote the transformation and proliferation of lymphocytes, and stimulate NK effector cell activity. At the same time, Ginseng-DF could restore the proportion of CD4+/CD8+ T lymphocytes induced by CTX to different extents, improved spleen tissue damage, promoted the secretion of immunoglobulin IgG, and enhanced body immunity. More importantly, Ginseng-DF could up-regulate the contents of TNF-alpha, IFN-gamma, IL-6 and IL-1 beta in serum and intestine of immunosuppressed mice to maintain the balance between Th1/Th2 cytokines, and improve the permeability of intestinal mucosal barrier. Meanwhile, Ginseng-DF could reduce intestinal epithelial cell apoptosis and improve intestinal adaptive immunity in CTX-induced immunosuppressed mice by regulating MAPK/NF-kappa B signaling pathway.ConclusionGinseng-DF can be used as a safe dietary supplement to enhance body immunity and reduce intestinal mucosal injury caused by CTX.
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