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Insights into the Epidemiology, Phylodynamics, and Evolutionary Changes of Lineage GI-7 Infectious Bronchitis Virus

文献类型： 外文期刊

作者： Chen, Libin 1 ; Jiang, Weiwei 1 ; Wu, Wanyan 1 ; Zhang, Siyuan 5 ; Cai, Juncheng 1 ; Lv, Ting 1 ; Xiang, Bin 6 ; Lin, Qiuyan 1 ; Liao, Ming 7 ; Ding, Chan 8 ; Ren, Tao 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

2.Minist Agr, Key Lab Anim Vaccine Dev, Guangzhou 510642, Peoples R China

3.Natl & Reg Joint Engn Lab Medicament Zoonosis Prev, Guangzhou 510642, Peoples R China

4.Key Lab Zoonosis Prevent & Control Guangdong Prov, Guangzhou 510642, Peoples R China

5.Guangzhou South China Biol Med Co Ltd, Guangzhou 510642, Peoples R China

6.Yunnan Agr Univ, Coll Vet Med, Kunming 650201, Peoples R China

7.Minist Agr & Rural Affairs, Key Lab Prevent & Control Avian Influenza & Other, Guangzhou 510642, Peoples R China

8.Chinese Acad Agr Sci CAAS, Shanghai Vet Res Inst SHVRI, Shanghai 200241, Peoples R China

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 1865-1674

年卷期： 2023 年 2023 卷

页码：

收录情况： SCI

摘要： Infectious bronchitis virus (IBV) is distributed worldwide and causes significant losses in the poultry industry. In recent decades, lineages GI-19 and GI-7 have become the most prevalent IBV strains in China. However, the molecular evolution and phylodynamics of the lineage GI-7 IBV strains remain largely unknown. In this study, we identified 19 IBV strains from clinical samples from January 2021 to June 2022 in China, including 12 strains of GI-19, 3 strains of GI-7, and 1 strain each of GI-1, GI-9, GI-13, and GI-28. These results indicated that lineages GI-19 and GI-7 IBVs are still the most prevalent IBVs in China. Here, we investigated the evolution and transmission dynamics of lineage GI-7 IBVs. Our results revealed that the Taiwan province might be the origin of lineage GI-7 IBVs and that South China plays an important role in the spread of IBV. Furthermore, we found low codon usage bias of the S1 gene in lineage GI-7 IBVs. This allowed IBV to replicate in the host during evolution as a result of reduced competition, mainly driven by natural selection and mutational pressure, where the role of natural selection is more prominent. Collectively, our results reveal the genetic diversity and evolutionary dynamics of lineage GI-7 IBVs, which could assist in the prevention and control of viral infection.

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