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Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+T Cells, Gut Microbiota, and Bacterial Metabolites

文献类型： 外文期刊

作者： Xu, Yingyin 1 ; Xie, Liyuan 1 ; Zhang, Zhiyuan 1 ; Zhang, Weiwei 3 ; Tang, Jie 1 ; He, Xiaolan 1 ; Zhou, Jie 1 ; Peng, We 1 ;

作者机构： 1.Sichuan Acad Agr Sci, Soil & Fertilizer Inst, Natl Local Joint Engn Lab Breeding & Cultivat Edi, Chengdu, Peoples R China

2.Minist Agr, Sci Observing & Expt Stn Agromicrobial Resource &, Chengdu, Peoples R China

3.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing, Peoples R China

关键词： colitis; gut microbiota; inflammatory responses; microbial metabolites; Tremella fuciformis polysaccharides

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：5.085； 五年影响因子：5.733 ）

ISSN： 1664-3224

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： Tremella fuciformis is an edible medicinal mushroom, and its polysaccharide components are found to confer various health benefits. This study identified the protective effects of polysaccharides of Tremella fuciformis (TPs) against dextran sulfate sodium (DSS)-induced colitis in mice. High dose of TPs (HTPs) could prevent the colon from shortening, reduce activity of colonic myeloperoxidase and serum diamine oxidase (DAO), decrease the concentration of D-lactate, and alleviate the colonic tissue damage in colitic mice. HTPs treatment stimulated Foxp3+T cells, and promoted the production of anti-inflammatory cytokines whereas it reduced the production of pro-inflammatory and the portion of immunoglobulin A (IgA)-coated bacteria, which was related to modulation of immune responses. 16S rRNA sequencing analysis showed that TPs could significantly increase gut community diversity, and restore the relative abundances of Lactobacillus, Odoribacter, Helicobacter, Ruminococcaceae, and Marinifilaceae. According to metabolomic analysis, HTPs induced specific microbial metabolites akin to that in normal mice. Tyrosine biosynthesis, tryptophan metabolism, and bile acid metabolism were influenced in the HTPs group compared with those in the DSS group. HTPs could alleviate DSS-induced colitis by immunoregulation and restored the gut microbiota and microbial metabolites. The results indicated that HTPs have potential to be developed as a food supplement to ameliorate intestinal diseases.

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