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Assessing the effect of composted cyclosporin A fermentation residue as organic fertilizer: Focus on soil fertility and antibiotic resistance

文献类型： 外文期刊

作者： Wang, Dong 1 ; Chen, Xiang 1 ; Li, Xiaofen 1 ; Zhang, Qingwen 2 ; Hou, Jiaqi 3 ; Li, Yuefei 1 ; Xi, Beidou 3 ; Sun, Zhihao 1 ; Xin, Shuaishuai 1 ; Liu, Guocheng 1 ; Liu, Huiling 4 ; Xin, Yanjun 1 ;

作者机构： 1.Qingdao Agr Univ, Coll Resources & Environm, Qingdao Engn Res Ctr Rural Environm, Qingdao 266109, Peoples R China

2.Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Agr Clean Watershed Grp, Beijing 100081, Peoples R China

3.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China

4.Tongji Univ, Sch Environm Sci & Engn, Shanghai 200092, Peoples R China

5.Agr Dept, Key Lab Microalgal Resources Agr Utilisat, Jiujiang 332700, Jiangxi, Peoples R China

关键词： Cyclosporin A; Antibiotic fermentation residue; Soil fertility; Ntibiotic resistance gene

期刊名称：JOURNAL OF ENVIRONMENTAL SCIENCES （ 影响因子：6.3； 五年影响因子：6.1 ）

ISSN： 1001-0742

年卷期： 2025 年 157 卷

页码：

收录情况： SCI

摘要： Cyclosporin A fermentation residue (CFR) is a type of organic waste generated during the production of cyclosporin A, which are abundant in nutrients including organic matter, phosphorus, nitrogen and potassium. Inappropriate handling of CFR not only waste valuable bioresources, but may also lead to the cyclosporin A and associated resistance genes into the natural environment, posing a significant threat to ecological system and human health. Land application was an effective way to resource recovery of CFR after aerobic composting (CAC). This study investigated the impact of CAC on soil fertility and environmental safety. The results indicated that CAC could improve soil nutrient contents and enhance enzyme activities. CAC altered the diversity and community composition of soil bacteria, resulting in an increase in the abundance of relevant bacteria beneficial for organic matter decomposition and cyclosporin A degradation. The introduced cyclosporin A (71.69 pg/kg) completely degraded within 20 days due to soil biodegradation. The significantly increased abundance of intIl, mdr3, pgp, TSR and pmra in the soil cultivation early stage were restored to the soil background level within 90 days, indicating a reduced risk of antimicrobial resistance. The results demonstrated that reasonable land application of CAC could improve soil fertility without antimicrobial resistance risk, which is helpful for evaluating the resource utilization value and environmental risks of antibiotic fermentation residue after aerobic composting. (c) 2025 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.

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