Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats
文献类型： 外文期刊
作者： Belay, Shumuye 1 ; Belay, Gurja 2 ; Nigussie, Helen 2 ; Ahbara, Abulgasim M. 3 ; Tijjani, Abdulfatai 5 ; Dessie, Tadelle 6 ; Tarekegn, Getinet M. 3 ; Jian-Lin, Han 8 ; Mor, Siobhan 6 ; Woldekiros, Helina S. 11 ; Dobney, Keith 12 ; Lebrasseur, Ophelie 14 ; Hanotte, Olivier 6 ; Mwacharo, Joram M. 3 ;
作者机构： 1.Tigray Agr Res Inst, Mekelle, Ethiopia
2.Addis Ababa Univ, Dept Microbial Cellular & Mol Biol, Addis Ababa, Ethiopia
3.Scotlands Rural Coll SRUC, Anim & Vet Sci, Roslin Inst Bldg, Midlothian, Scotland
4.Misurata Univ, Dept Zool, Misurata, Libya
5.Jackson Lab, Bar Harbor, ME 04609 USA
6.Int Livestock Res Inst ILRI, Addis Ababa, Ethiopia
7.Addis Ababa Univ, Inst Biotechnol IoB, Addis Ababa, Ethiopia
8.CAAS ILRI Joint Lab Livestock & Forage Genet Resou, Beijing, Peoples R China
9.Chinese Acad Agr Sci CAAS, Inst Anim Sci, Beijing, Peoples R China
10.Univ Liverpool, Inst Infect Vet & Ecol Sci, Liverpool, England
11.Washington Univ St Louis, Dept Anthropol, St Louis, MO USA
12.Univ Liverpool, Dept Archaeol Class & Egyptol, Liverpool, Merseyside, England
13.Univ Sydney, Sydney, Australia
14.Univ Oxford, Sch Archaeol, Palaeogen & Bioarchaeol Res Network, Oxford, England
15.Univ Nottingham, Sch Life Sci, Nottingham, England
16.Int Ctr Agr Res Dry Areas ICARDA, Small Ruminant Genom, Addis Ababa, Ethiopia
期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.8； 五年影响因子：4.3 ）
ISSN： 2045-2322
年卷期： 2024 年 14 卷 1 期
页码：
收录情况： SCI
摘要： Anthropological and biophysical processes have shaped livestock genomes over Millenia and can explain their current geographic distribution and genetic divergence. We analyzed 57 Ethiopian indigenous domestic goat genomes alongside 67 equivalents of east, west, and north-west African, European, South Asian, Middle East, and wild Bezoar goats. Cluster, ADMIXTURE (K = 4) and phylogenetic analysis revealed four genetic groups comprising African, European, South Asian, and wild Bezoar goats. The Middle Eastern goats had an admixed genome of these four genetic groups. At K = 5, the West African Dwarf and Moroccan goats were separated from East African goats demonstrating a likely historical legacy of goat arrival and dispersal into Africa via the coastal Mediterranean Sea and the Horn of Africa. FST, XP-EHH, and Hp analysis revealed signatures of selection in Ethiopian goats overlaying genes for thermo-sensitivity, oxidative stress response, high-altitude hypoxic adaptation, reproductive fitness, pathogen defence, immunity, pigmentation, DNA repair, modulation of renal function and integrated fluid and electrolyte homeostasis. Notable examples include TRPV1 (a nociception gene); PTPMT1 (a critical hypoxia survival gene); RETREG (a regulator of reticulophagy during starvation), and WNK4 (a molecular switch for osmoregulation). These results suggest that human-mediated translocations and adaptation to contrasting environments are shaping indigenous African goat genomes.
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