5 '-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity
文献类型： 外文期刊
作者： Chen, Fang 1 ; Song, Chengchuang 1 ; Meng, Fantong 1 ; Zhu, Yuhua 1 ; Chen, Xi 1 ; Fang, Xingtang 1 ; Ma, Daifu 4 ; Wang, Yanhong 1 ; Zhang, Chunlei 1 ;
作者机构： 1.Jiangsu Normal Univ, Inst Cellular & Mol Biol, Coll Life Sci, Xuzhou 221116, Jiangsu, Peoples R China
2.Jiangsu Normal Univ, Lab Phylogen & Comparat Genom, Xuzhou 221116, Jiangsu, Peoples R China
3.Xuzhou Med Univ, Lab Anim Ctr, Xuzhou 221004, Jiangsu, Peoples R China
4.Chinese Acad Agr Sci, Xuzhou Inst Agr Sci Jiangsu Xuhuai Dist, Sweetpotato Res Inst, Key Lab Biol & Genet Improvement Sweetpotato,Minis, Xuzhou 221004, Jiangsu, Peoples R China
关键词： 5?-tRF-GlyGCC; BC; m6A; Autophagy; Tumor metastasis
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）
ISSN： 0141-8130
年卷期： 2023 年 226 卷
页码：
收录情况： SCI
摘要： tRNA-derived fragments (tRFs) are a class of regulatory non-coding RNAs that play essential biological functions in cancer and stress-induced diseases. Several lines of evidence suggest that 5 '-tRF-GlyGCC participates in tumor progression; however, its molecular mechanisms remain unclear. In this study, we explored the function of 5 '- tRF-GlyGCC in breast cancer (BC) progression and studied the related potential molecular mechanisms. 5 '-tRF-GlyGCC expression increased in human BC, and it promoted the proliferation, migration, and invasion of BC cells in vitro and tumor growth and metastasis in vivo. 5 '-tRF-GlyGCC was found for the first time to bind directly to fat mass and obesity-associated proteins, and increase the activity of FTO demethylase, reducing eIF4G1 methyl-ation, inhibiting autophagy, and promoting BC proliferation and metastasis. These findings suggest that 5 '-tRF-GlyGCC might be a therapeutic target for treating BC.
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