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Exploring Allium mongolicum Regel flavonoids alleviation of deoxynivalenol-induced gut inflammation and flesh-quality improvement based on muscle-intestinal axis in a Channa argus model

文献类型： 外文期刊

作者： Yu, Zhe 2 ; Xiong, Zhuang 1 ; Wang, Yi 2 ; Gao, Zhi-Qiang 3 ; Lu, Ke-Xin 1 ; Zhang, Ying 4 ; Li, Mu-Yang 3 ; Yue, Yuan-Xi 1 ;

作者机构： 1.Jining Med Univ, Sch Life Sci, Rizhao 276800, Shandong, Peoples R China

2.Chinese Acad Agr Sci, Inst Feed Res, Beijing 100081, Peoples R China

3.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Heilongjiang, Peoples R China

4.Freshwater Fisheries Res Inst Jilin Prov, Changchun 130000, Jilin, Peoples R China

关键词： AMRF; DON; Channa argus; Muscle-intestinal axis; Inflammation; Flesh quality

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 71 卷

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) was widely found in plant-derived feed, threatening the animal health and food safety. Allium mongolicum Regel flavonoids (AMRF) is a natural plant extract with a variety of biological functions, but whether it can alleviate DON-induced biotoxicity remains unknown. Hence, the effect of DON-induced gut-inflammation and flesh-quality in Channa argus by AMRF were examined. DON (2 mg/kg) and AMRF (40 mg/kg) were supplemented to the basic formula feed to develop three dietary groups and C. argus were fed for 8 weeks. The results showed that feed supplement AMRF significantly alleviated DON-induced growth inhibition, increased digestive enzymes activities, and enhanced intestinal detoxification of DON, which directly led to a significant reduction (P<0.05) of toxin residues in fish. Meanwhile, the inflammatory response (nf-kappa b, i-kappa b, tnf-alpha, il-1 beta, il-2, il-6, il-8, ifn-gamma) was also alleviated (P<0.05), and AMRF alleviated DON-induced inflammation possibly through the TRAF6/Sufu/p-p65-related pathway. Furthermore, inflammatory response also induced changes in gut microbiota (P<0.05), i.e., increased abundance of Cetobacterium and decreased Nostocaceae. Additionally, AMRF increased muscle protein content and antioxidant capacity, improved textural properties, and reduced fishy substances (P<0.05). This study provides valuable insights to elucidate the potential mechanisms by which AMRF mitigates DON toxicity.

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