Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance
文献类型： 外文期刊
作者： Shang, Shengping 1 ; He, Yuhan 1 ; Zhao, Ruihua 1 ; Li, Hanqi 1 ; Fang, Ying 1 ; Hu, Qianyong 1 ; Fan, Yujin 1 ; Wang, Yiwei 1 ; Zhou, Xishi 1 ; Wang, Penghao 3 ; Xing, Xiaoping 2 ; Zhang, Cui-Jun 1 ;
作者机构： 1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Key Lab Synthet B, Shenzhen, Peoples R China
2.Henan Agr Univ, Coll Plant Protect, Zhengzhou, Peoples R China
3.Murdoch Univ, Food Futures Inst, Ctr Crop & Food Innovat, Sch Agr Sci, Perth, WA, Australia
4.Shanxi Agr Univ, Coll Agr, Taigu, Shanxi, Peoples R China
5.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China
6.Taiyuan Univ Technol, Coll Data Sci, Taiyuan, Peoples R China
7.Murdoch Univ, Coll Sci Hlth Engn & Educ, Sch Med Mol & Forens Sci, Murdoch, WA, Australia
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2025 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Fusarium head blight (FHB), caused by Fusarium graminearum is a devastating disease that affects global wheat production. F. graminearum encodes many effector proteins; however, its virulence mechanisms are poorly understood. In this study, we identify a secretory effector candidate (FgEC10) that is essential for the virulence of F. graminearum. FgEC10 interacts strongly with wheat fumarylacetoacetate hydrolase (TaFAH) and accelerates its degradation via the 26S proteasome pathway. In addition, we show that TaFAH interacts with proteasome 26S subunit, non-ATPases 12 (TaPSMD12) and that FgEC10 enhances the interaction between TaFAH and TaPSMD12. RNA silencing or overexpression of TaFAH in wheat plants shows that TaFAH positively regulates wheat FHB resistance. Overexpression of TaFAH promotes the expression of genes associated with disease resistance and the heading period. Metabolomic analysis reveals that overexpression of TaFAH increases the levels of several amino acids in wheat, and exogenous application of some of these amino acids show an increase in F. graminearum resistance in the wheat spike and seedling. Collectively, our study reveals a pathogenic mechanism and provides a valuable gene resource for improving FHB resistance and promoting heading in wheat.
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