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Detoxification and neurotransmitter clearance drive the recovery of Arma chinensis from ll-cypermethrin-triggered knockdown

文献类型： 外文期刊

作者： Wang, Zhen 1 ; He, Wenjie 1 ; Fu, Luyao 1 ; Cheng, Hongmei 1 ; Lin, Changjin 1 ; Dong, Xiaolin 2 ; Liu, Chenxi 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, Sino Amer Biol Control Lab, Beijing 100193, Peoples R China

2.Yangtze Univ, Dept Entomol, Jingzhou 434023, Peoples R China

关键词： ll-cypermethrin; Trans-regulation; Recovery; Detoxification; Neurotransmitter

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：12.2； 五年影响因子：11.9 ）

ISSN： 0304-3894

年卷期： 2024 年 476 卷

页码：

收录情况： SCI

摘要： Natural enemies of arthropods contribute considerably to agriculture by suppressing pests, particularly when combined with chemical control. Studies show that insect recovery after insecticide application is rare. Here, we discovered the recovery of the predatory bug Arma chinensis from knockdown following the application of ll-cypermethrin but not five other insecticides. A. chinensis individuals were more tolerant to ll-cypermethrin than lepidopteran and coleopteran larvae, which did not recover from knockdown. We assessed A. chinensis recovery by monitoring their respiration and tracking locomotion through the entire process. We identified and verified the trans-regulation of detoxifying genes, including those encoding cytochrome P450s and a/ll-hydrolase, which confer recovery from ll-cypermethrin exposure in A. chinensis, by mitogen-activated protein kinase (MAPK) and cAMP response element binding protein (CREB). Furthermore, we discovered a novel mechanism, the neurotransmitter clearance, in vivo during the recovery process, by which the insect initiated the removal of excessive dopamine with a degrading enzyme ebony. Overall, these results provide mechanistic insights into the detoxification and neurotransmitter clearance that jointly drive insect recovery from insecticide exposure.

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