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Attenuation by Zhiqiao neohesperidin on dextran sulfate sodium-induced colitis in mice through inhibition of the TLR4/NF-κB pathway

文献类型： 外文期刊

作者： Li, Guijie 1 ; Wang, Xuting 1 ; Long, Xingyao 4 ; Chen, Shanshan 1 ; Han, Leng 1 ; Cheng, Yujiao 1 ; Chen, Suyang 5 ; Liu, Wenwen 6 ; Feng, Ruizhang 6 ; Sun, Zhigao 1 ;

作者机构： 1.Southwest Univ, Citrus Res Inst, Chongqing 400712, Peoples R China

2.Chinese Acad Agr Sci, Citrus Res Ctr, Chongqing 400712, Peoples R China

3.Natl Citrus Engn Res Ctr, Chongqing 400712, Peoples R China

4.Chongqing Univ Educ, Collaborat Innovat Ctr Child Nutr & Hlth Dev, Chongqing 400067, Peoples R China

5.Taixing Peoples Hosp, Taixing 225451, Jiangsu, Peoples R China

6.Yibin Univ, Key Lab Aromat Plant Resources Exploitat & Utiliza, Yibin 644000, Sichuan, Peoples R China

关键词： Citrus aurantium; Neohesperidin; Aqueous two-phase extraction; Ulcerative colitis; TLR4 signaling; Inflammation; Molecular docking

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2024 年 62 卷

页码：

收录情况： SCI

摘要： Ulcerative colitis is a chronic inflammatory disease closely associated with immune dysregulation. Zhiqiao (Fructus aurantii), the nearly mature fruit of Citrus aurantium L., is widely used in traditional dietary therapy for intestinal health. Here, we extracted and purified neohesperidin from Zhiqiao and explored its alleviative effects on dextran sulfate sodium-induced colitis and related inflammatory pathways in mice. The results showed that neohesperidin administration significantly ameliorated symptoms of colitis and reduced the accumulation of inflammatory cytokines in mouse tissues and serum. Decreases in the TLR4, MyD88, and NF-kappa B p65 mRNA expression levels indicated that activity of the TLR4/NF-kappa B signaling pathway was downregulated. Molecular docking results showed that neohesperidin occupies the lipopolysaccharide-binding pocket of MD-2 and binds to the interacting surface of TLR4/MD-2 and that of the subsequently formed homodimer, thereby disrupting recognition of inflammatory ligands by the TLR4-mediated pathway. Neohesperidin holds promise for the adjunctive treatment of ulcerative colitis.

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