文献类型： 外文期刊
作者： Gong, Jiatai 1 ; Zhang, Qianjin 1 ; Hu, Ruizhi 1 ; Yang, Xizi 1 ; Fang, Chengkun 1 ; Yao, Liping 1 ; Lv, Jing 1 ; Wang, Long 1 ; Shi, Mingkun 1 ; Zhang, Wentao 1 ; Ma, Siqi 1 ; Xiang, Hongkun 1 ; Zhang, Hongfu 1 ; Hou, De-Xing 1 ; Yin, Yulong 1 ; He, Jianhua 1 ; Peng, Lijun 4 ; Wu, Shusong 1 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
3.Kagoshima Univ, Fac Agr, Dept Food Sci & Biotechnol, Korimoto, Kagoshima, Japan
4.Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Childrens Healthcare Inst, Changsha 410007, Hunan, Peoples R China
关键词： Obesity; prevotella copri; insulin; gut microbiota; bile acids
期刊名称：GUT MICROBES （ 影响因子：12.2； 五年影响因子：12.4 ）
ISSN： 1949-0976
年卷期： 2024 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and interleukin-1 beta (IL-1 beta) (p < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that P. copri reduced the relative abundance of the Akkermansia genus in mice (p < 0.01). Further analysis on bile acids (BAs) revealed that P. copri increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice (p < 0.05). This study demonstrated for the first time that P. copri has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of Akkermansia genus and bile acids.
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