您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Green synthesis of silver nanoparticles using Fructus Aurantii-loaded Citrus pectin hydrogel for accelerated healing of MRSA-infected diabetic wounds

文献类型： 外文期刊

作者： Chang, Li 1 ; Ahmad, Bilal 1 ; Tong, Aidi 1 ; Wu, Zhou 1 ; Xu, Pengxiang 1 ; Gao, Zexin 2 ; Yin, Caiyun 1 ; Luan, Mingbao 2 ; Tong, Chunyi 1 ; Liu, Bin 1 ;

作者机构： 1.Hunan Univ, Coll Biol, Changsha 410082, Peoples R China

2.Chinese Acad Agr Sci, Inst Bast Fiber Crop, Changsha 410304, Peoples R China

3.Chinese Acad Agr Sci, Natl Nanfan Res Inst, Sanya 572000, Peoples R China

4.Chinese Acad Agr Sci, Inst Bast Fiber Crop, Changsha 410082, Peoples R China

关键词： Green synthesis; Fructus Aurantii-silver nanoparticles; Citrus pectin; Hydrogel; MRSA-infected diabetic wound

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 315 卷

页码：

收录情况： SCI

摘要： To address the challenges of bacterial infection and wound healing in diabetic wounds, we developed a multibioactive citrus pectin hydrogel (CPH) loaded with Fructus Aurantii-derived green synthesized silver nano-particles (FA-Ag NPs), termed FA-Ag NPs/CPH. Here, FA-Ag NPs exhibited excellent antibacterial activity alongside antioxidant, anti-inflammatory and wound-healing activities. When combined with CPH, this formulation significantly enhanced biocompatibility and accelerated wound repair processes. In vitro experiments demonstrated sustained release of FA-Ag NPs, achieving a 97.66 % eradication rate against methicillin-resistant Staphylococcus aureus (MRSA) through disrupting bacterial membrane integrity by inducing intracellular content leakage and inhibiting ATP synthesis. The hydrogel also demonstrated antioxidant and anti-inflammatory activities, promoting cell migration and angiogenesis. In vivo assays showed that FA-Ag NPs/CPH reduced wound area to 8 % by day 11 (vs. 23.4 % in control group). This therapeutic effect was attributable to suppressing MRSA infection, promoting macrophage polarization from pro-inflammatory M1 to reparative M2 phenotype, accelerating cellular migration and neovascularization, stimulating collagen deposition, and promoting skin appendage development. Collectively, these findings confirm the combined antibacterial and wound-healing efficacy of FA-Ag NPs/CPH with superior biocompatibility, highlighting its promising clinical application potential. However, further validation of long-term biological effects through large animal studies is still required.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台