Bacteriophages inhibit and evade cGAS-like immune function in bacteria
文献类型: 外文期刊
第一作者: Huiting, Erin
作者: Huiting, Erin;Silas, Sukrit;Carion, Heloise;Bondy-Denomy, Joseph;Luo, Zhaorong;An, Na;Feng, Yue;Ren, Jie;Zhou, Yu;Fraser, James S.;Bondy-Denomy, Joseph;Bondy-Denomy, Joseph
作者机构:
期刊名称:CELL ( 影响因子:64.5; 五年影响因子:57.5 )
ISSN: 0092-8674
年卷期: 2023 年 186 卷 4 期
页码:
收录情况: SCI
摘要: A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which synthesizes 2',3'-cGAMP and activates the effector STING. Diverse bacteria contain cGAS-like enzymes that produce cy-clic oligonucleotides and induce anti-phage activity, known as CBASS. However, this activity has only been demonstrated through heterologous expression. Whether bacteria harboring CBASS antagonize and co -evolve with phages is unknown. Here, we identified an endogenous cGAS-like enzyme in Pseudomonas aer-uginosa that generates 3 ',3 '-cGAMP during phage infection, signals to a phospholipase effector, and limits phage replication. In response, phages express an anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity. Acb2 also binds to molecules pro-duced by other bacterial cGAS-like enzymes (3 ',3 '-cUU/UA/UG/AA) and mammalian cGAS (2',3'-cGAMP), suggesting broad inhibition of cGAS-based immunity. Upon Acb2 deletion, CBASS blocks lytic phage repli-cation and lysogenic induction, but rare phages evade CBASS through major capsid gene mutations. Alto-gether, we demonstrate endogenous CBASS anti-phage function and strategies of CBASS inhibition and evasion.
分类号:
- 相关文献
作者其他论文 更多>>
-
Absolute quantification of microRNAs based on mass transport limitation under a laminar flow SPR system
作者:Li, Kai;An, Na;Wang, Min;Li, Fukai;Li, Liang;Wu, Liqing
关键词:Surface plasmon resonance; Mass transport limitation; Biosensor; Absolute quantification; microRNA
-
Quantifying the relative contribution of driving factors to the transformation of bauxite residue into a plant growth substrate
作者:Tang, Shiming;Zhang, Xi;Ren, Xueqian;Ren, Jie;Du, Ping
关键词:Bauxite residue; Organic materials; Soil -like mediate; Aggregate; stability
-
The nutritional composition of the vegetable soybean (maodou) and its potential in combatting malnutrition
作者:Agyenim-Boateng, Kwadwo Gyapong;Zhang, Shengrui;Zhang, Shibi;Khattak, Aimal Nawaz;Shaibu, Abdulwahab;Abdelghany, Ahmed M.;Qi, Jie;Azam, Muhammad;Ma, Caiyou;Feng, Yue;Feng, Huoyi;Liu, Yitian;Li, Jing;Li, Bin;Sun, Junming
关键词:soybean (Glycine max L; Merrill); maodou; macronutrients; micronutrients; malnutrition
-
Population Genetic Analysis of a Bread Wheat Panel from Northern and Huang-Huai Agro-Ecological Regions in China
作者:Jin, Xiaojie;Song, Zheng;Zhao, Xiaobin;Peng, Yanchun;Jin, Xiaojie;Liu, Qian;Zhao, Yun;Zhang, Yingjun;Gao, Huimin;He, Wenchuang;Wang, Guijuan;Ren, Xifeng;Zhou, Yu;Ren, Xifeng
关键词:bread wheat; SNP; population structure; genetic diversity; ancestry informative markers
-
Bacterial Community Structure in Rhizosphere of Barley at Maturity Stage
作者:Zhang, Siyu;An, Yue;Zhou, Yu;Wang, Xiaofang;Ren, Xifeng;Tang, Yiqing;Zhang, Daorong;Sun, Genlou;Wang, Qifei
关键词:barley; maturity period; rhizosphere; bacterial community; structural characteristics
-
Promising potential of machine learning-assisted MALDI-TOF MS as an effective detector for Streptococcus suis serotype 2 and virulence thereof
作者:Wang, Zhuohao;Zhou, Yu;Guo, Genglin;Zhang, Wei;Wang, Zhuohao;Zhou, Yu;Guo, Genglin;Zhang, Wei;Wang, Zhuohao;Zhou, Yu;Guo, Genglin;Zhang, Wei;Wang, Zhuohao;Zhou, Yu;Guo, Genglin;Zhang, Wei;Li, Quan;Yu, Yanfei
关键词:Streptococcus suis; serotyping; subtyping; virulence; MALDI-TOF MS; machine learning
-
A transcription factor ZmGLK36 confers broad resistance to maize rough dwarf disease in cereal crops
作者:Xu, Zhennan;Zhou, Zhiqiang;Cheng, Zixiang;Wang, Feifei;Li, Mingshun;Li, Gongjian;Li, Wenxue;Du, Qingguo;Wang, Ke;Lu, Xin;Tai, Yuxin;Chen, Runyi;Hao, Zhuanfang;Han, Jienan;Yong, Hongjun;Zhang, Degui;Weng, Jianfeng;Li, Xinhai;Zhou, Yu;Wang, Zhenhua;Chen, Yanping;Meng, Qingchang;Kong, Xiaomin;Tie, Shuanggui;Mu, Chunhua;Song, Weibin;Wang, Haiyang
关键词: